Evidence for dopaminergic involvement in endogenous modulation of pain relief

• Verfasst von: Desch, Simon [VerfasserIn]
• Verfasst von: Schweinhardt, Petra [VerfasserIn]
• Verfasst von: Seymour, Ben [VerfasserIn]
• Verfasst von: Flor, Herta [VerfasserIn]
• Verfasst von: Becker, Susanne [VerfasserIn]
• Titel: Evidence for dopaminergic involvement in endogenous modulation of pain relief
• Verf.angabe: Simon Desch, Petra Schweinhardt, Ben Seymour, Herta Flor, Susanne Becker
• E-Jahr: 2023
• Jahr: 01 February 2023
• Umfang: 27 S.
• Fussnoten: Gesehen am 28.04.2023
• Titel Quelle: Enthalten in: eLife
• Ort Quelle: Cambridge : eLife Sciences Publications, 2012
• Jahr Quelle: 2023
• Band/Heft Quelle: 12(2023), Artikel-ID e81436, Seite 1-27
• ISSN Quelle: 2050-084X
• DOI: doi:10.7554/eLife.81436
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: dopamine
• Sach-SW: endogenous opioids
• Sach-SW: endogenous pain modulation
• Sach-SW: learning
• Sach-SW: pain relief
• Sach-SW: prediction error
• K10plus-PPN: 1843777916

Abstract

Relief of ongoing pain is a potent motivator of behavior, directing actions to escape from or reduce potentially harmful stimuli. Whereas endogenous modulation of pain events is well characterized, relatively little is known about the modulation of pain relief and its corresponding neurochemical basis. Here, we studied pain modulation during a probabilistic relief-seeking task (a ‘wheel of fortune’ gambling task), in which people actively or passively received reduction of a tonic thermal pain stimulus. We found that relief perception was enhanced by active decisions and unpredictability, and greater in high novelty-seeking trait individuals, consistent with a model in which relief is tuned by its informational content. We then probed the roles of dopaminergic and opioidergic signaling, both of which are implicated in relief processing, by embedding the task in a double-blinded cross-over design with administration of the dopamine precursor levodopa and the opioid receptor antagonist naltrexone. We found that levodopa enhanced each of these information-specific aspects of relief modulation but no significant effects of the opioidergic manipulation. These results show that dopaminergic signaling has a key role in modulating the perception of pain relief to optimize motivation and behavior.