Status: Bibliographieeintrag
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| Verfasst von: | Ceranski, Katharina [VerfasserIn]  |
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| | Carreño-Gonzalez, Martha J. [VerfasserIn] |
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| | Ehlers, Anna C. [VerfasserIn] |
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| | Colombo, Maria Vittoria [VerfasserIn] |
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| | Cidre-Aranaz, Florencia [VerfasserIn] |
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| | Grünewald, Thomas G. P. [VerfasserIn] |
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| Titel: | Hypoxia and HIFs in Ewing sarcoma |
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| Titelzusatz: | new perspectives on a multi-facetted relationship |
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| Verf.angabe: | A. Katharina Ceranski, Martha J. Carreño-Gonzalez, Anna C. Ehlers, Maria Vittoria Colombo, Florencia Cidre-Aranaz and Thomas G.P. Grünewald |
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| E-Jahr: | 2023 |
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| Jahr: | 13 March 2023 |
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| Umfang: | 15 S. |
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| Illustrationen: | Diagramme |
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| Fussnoten: | Gesehen am 05.12.2023 |
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| Titel Quelle: | Enthalten in: Molecular cancer |
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| Ort Quelle: | London : Biomed Central, 2002 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 22(2023), Artikel-ID 49, Seite 1-15 |
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| ISSN Quelle: | 1476-4598 |
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| Abstract: | Hypoxia develops during the growth of solid tumors and influences tumoral activity in multiple ways. Low oxygen tension is also present in the bone microenvironment where Ewing sarcoma (EwS) - a highly aggressive pediatric cancer - mainly arises. Hypoxia inducible factor 1 subunit alpha (HIF-1-a) is the principal molecular mediator of the hypoxic response in cancer whereas EWSR1::FLI1 constitutes the oncogenic driver of EwS. Interaction of the two proteins has been shown in EwS. Although a growing body of studies investigated hypoxia and HIFs in EwS, their precise role for EwS pathophysiology is not clarified to date. This review summarizes and structures recent findings demonstrating that hypoxia and HIFs play a role in EwS at multiple levels. We propose to view hypoxia and HIFs as independent protagonists in the story of EwS and give a perspective on their potential clinical relevance as prognostic markers and therapeutic targets in EwS treatment. |
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| DOI: | doi:10.1186/s12943-023-01750-w |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1186/s12943-023-01750-w |
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| | kostenfrei: Volltext: https://molecular-cancer.biomedcentral.com/articles/10.1186/s12943-023-01750-w |
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| | DOI: https://doi.org/10.1186/s12943-023-01750-w |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | ARNT |
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| | Ewing sarcoma |
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| | HIF-1-a |
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| | HIF-1-b |
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| | hypoxia |
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| K10plus-PPN: | 1844066975 |
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| Verknüpfungen: | → Zeitschrift |
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Hypoxia and HIFs in Ewing sarcoma / Ceranski, Katharina [VerfasserIn]; 13 March 2023 (Online-Ressource)
69070395
