Status: Bibliographieeintrag
Standort: ---
Exemplare:
---
| Online-Ressource |
Verfasst von: | Maier, Patrick [VerfasserIn]  |
| Kalle, Christof von [VerfasserIn]  |
| Maier-Laufs, Stephanie [VerfasserIn]  |
Titel: | Retroviral vectors for gene therapy |
Verf.angabe: | Patrick Maier, Christof von Kalle, Stephanie Laufs |
E-Jahr: | 2010 |
Jahr: | 12 Nov 2010 |
Umfang: | 7 S. |
Fussnoten: | Gesehen am 02.05.2023 |
Titel Quelle: | Enthalten in: Future microbiology |
Ort Quelle: | London : Future Medicine Ltd, 2006 |
Jahr Quelle: | 2010 |
Band/Heft Quelle: | 5(2010), 10, Seite 1507-1523 |
ISSN Quelle: | 1746-0921 |
Abstract: | Since their first clinical trial 20 years ago, retroviral (gretroviral and lentiviral) vectors have now been used in more than 350 gene-therapy studies. Retroviral vectors are particularly suited for gene-correction of cells due to long-term and stable expression of the transferred transgene(s), and also because little effort is required for their cloning and production. Several monogenic inherited diseases, mostly immunodeficiencies, can now be successfully treated. The occurrence of insertional mutagenesis in some studies allowed extensive analysis of integration profiles of retroviral vectors, as well as the design of lentiviral vectors with increased safety properties. These new-generation vectors will enable us to continue the successful story of gene therapy, and treat more patients and even more complex diseases. |
DOI: | doi:10.2217/fmb.10.100 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.2217/fmb.10.100 |
| Volltext: https://www.futuremedicine.com/doi/10.2217/fmb.10.100 |
| DOI: https://doi.org/10.2217/fmb.10.100 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | gene therapy |
| improved vector design |
| insertional mutagenesis |
| lentiviral vectors |
| retroviral vectors |
K10plus-PPN: | 1844069915 |
Verknüpfungen: | → Zeitschrift |
Retroviral vectors for gene therapy / Maier, Patrick [VerfasserIn]; 12 Nov 2010 (Online-Ressource)
69070399