| |  Online-Ressource |
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| Verfasst von: | Montag, Christian [VerfasserIn]  |
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| | Markett, Sebastian [VerfasserIn] |
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| | Basten, Ulrike [VerfasserIn] |
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| | Stelzel, Christine [VerfasserIn] |
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| | Fiebach, Christian [VerfasserIn] |
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| | Canli, Turhan [VerfasserIn] |
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| | Reuter, Martin [VerfasserIn] |
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| Titel: | Epistasis of the DRD2/ANKK1 Taq Ia and the BDNF Val66Met polymorphism impacts Novelty Seeking and Harm Avoidance |
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| Verf.angabe: | Christian Montag, Sebastian Markett, Ulrike Basten, Christine Stelzel, Christian Fiebach, Turhan Canli and Martin Reuter |
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| E-Jahr: | 2010 |
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| Jahr: | 21 April 2010 |
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| Umfang: | 8 S. |
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| Fussnoten: | Gesehen am 03.05.2023 |
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| Titel Quelle: | Enthalten in: Neuropsychopharmacology |
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| Ort Quelle: | London : Springer Nature, 1993 |
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| Jahr Quelle: | 2010 |
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| Band/Heft Quelle: | 35(2010), 9, Seite 1860-1867 |
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| ISSN Quelle: | 1740-634X |
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| Abstract: | Mounting evidence from animal studies show that the mesolimbic dopaminergic pathways are modulated by the brain-derived neurotrophic factor (BDNF). This study investigates in N=768 healthy Caucasian participants the influence of two prominent functional single-nucleotide polymorphisms (SNPs) on the BDNF gene (BDNF Val66Met SNP) and the ankyrin repeat and kinase domain containing 1 (ANKK1) gene (DRD2 Taq Ia/ANKK1 SNP) on the personality traits of Novelty Seeking and Harm Avoidance, which are mediated, in part, through dopaminergic mesolimbic circuitry. Carriers of the 66Met+/A1+ variant scored lowest on Novelty Seeking and highest on Harm Avoidance, compared to all other genotype groups. These participants are characterized by a relatively low D2 receptor density in the striatum and an impaired activity-dependent secretion of BDNF. This is one of the first genetic association studies to show a modulatory role for BDNF genetic variation on genetically mediated differences in the mesolimbic dopaminergic system in the context of human personality. |
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| DOI: | doi:10.1038/npp.2010.55 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1038/npp.2010.55 |
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| | Volltext: https://www.nature.com/articles/npp201055 |
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| | DOI: https://doi.org/10.1038/npp.2010.55 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Genetic variation |
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| | Personality |
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| K10plus-PPN: | 184447447X |
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| Verknüpfungen: | → Zeitschrift |
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Epistasis of the DRD2/ANKK1 Taq Ia and the BDNF Val66Met polymorphism impacts Novelty Seeking and Harm Avoidance / Montag, Christian [VerfasserIn]; 21 April 2010 (Online-Ressource)
