| Online-Ressource |
Verfasst von: | Montag, Christian [VerfasserIn]  |
| Markett, Sebastian [VerfasserIn]  |
| Basten, Ulrike [VerfasserIn]  |
| Stelzel, Christine [VerfasserIn]  |
| Fiebach, Christian [VerfasserIn]  |
| Canli, Turhan [VerfasserIn]  |
| Reuter, Martin [VerfasserIn]  |
Titel: | Epistasis of the DRD2/ANKK1 Taq Ia and the BDNF Val66Met polymorphism impacts Novelty Seeking and Harm Avoidance |
Verf.angabe: | Christian Montag, Sebastian Markett, Ulrike Basten, Christine Stelzel, Christian Fiebach, Turhan Canli and Martin Reuter |
E-Jahr: | 2010 |
Jahr: | 21 April 2010 |
Umfang: | 8 S. |
Fussnoten: | Gesehen am 03.05.2023 |
Titel Quelle: | Enthalten in: Neuropsychopharmacology |
Ort Quelle: | London : Springer Nature, 1993 |
Jahr Quelle: | 2010 |
Band/Heft Quelle: | 35(2010), 9, Seite 1860-1867 |
ISSN Quelle: | 1740-634X |
Abstract: | Mounting evidence from animal studies show that the mesolimbic dopaminergic pathways are modulated by the brain-derived neurotrophic factor (BDNF). This study investigates in N=768 healthy Caucasian participants the influence of two prominent functional single-nucleotide polymorphisms (SNPs) on the BDNF gene (BDNF Val66Met SNP) and the ankyrin repeat and kinase domain containing 1 (ANKK1) gene (DRD2 Taq Ia/ANKK1 SNP) on the personality traits of Novelty Seeking and Harm Avoidance, which are mediated, in part, through dopaminergic mesolimbic circuitry. Carriers of the 66Met+/A1+ variant scored lowest on Novelty Seeking and highest on Harm Avoidance, compared to all other genotype groups. These participants are characterized by a relatively low D2 receptor density in the striatum and an impaired activity-dependent secretion of BDNF. This is one of the first genetic association studies to show a modulatory role for BDNF genetic variation on genetically mediated differences in the mesolimbic dopaminergic system in the context of human personality. |
DOI: | doi:10.1038/npp.2010.55 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1038/npp.2010.55 |
| Volltext: https://www.nature.com/articles/npp201055 |
| DOI: https://doi.org/10.1038/npp.2010.55 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Genetic variation |
| Personality |
K10plus-PPN: | 184447447X |
Verknüpfungen: | → Zeitschrift |
Epistasis of the DRD2/ANKK1 Taq Ia and the BDNF Val66Met polymorphism impacts Novelty Seeking and Harm Avoidance / Montag, Christian [VerfasserIn]; 21 April 2010 (Online-Ressource)