Insulin-resistant brain state (IRBS) changes membrane composition of fatty acids in temporal and entorhinal brain cortices of rats

• Verfasst von: Plaschke, Konstanze [VerfasserIn]
• Verfasst von: Müller, Dorothea [VerfasserIn]
• Verfasst von: Hoyer, Siegfried [VerfasserIn]
• Titel: Insulin-resistant brain state (IRBS) changes membrane composition of fatty acids in temporal and entorhinal brain cortices of rats
• Titelzusatz: relevance to sporadic Alzheimer’s disease?
• Verf.angabe: Konstanze Plaschke, Dorothea Müller, Siegfried Hoyer
• E-Jahr: 2010
• Jahr: 07 December 2010
• Umfang: 4 S.
• Fussnoten: Gesehen am 04.05.2023
• Titel Quelle: Enthalten in: Journal of neural transmission
• Ort Quelle: Wien [u.a.] : Springer, 1950
• Jahr Quelle: 2010
• Band/Heft Quelle: 117(2010), 12 vom: Dez., Seite 1419-1422
• ISSN Quelle: 1435-1463
• DOI: doi:10.1007/s00702-010-0523-3
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Fatty acid
• Sach-SW: Insulin
• Sach-SW: IRBS
• Sach-SW: Sporadic Alzheimer’s disease
• K10plus-PPN: 1844590046

Abstract

An insulin-resistant brain state (IRBS) was induced by intracerebroventricular application of the diabetogenic substance streptozotocin (STZ) to investigate changes in cerebral fatty acids. Six weeks after the first STZ injection, increases were found in the concentrations of palmitic and stearic acid in temporal cortex; and of palmitic acid in entorhinal cortex indicative of membrane phospholipid breakdown, and damage of the membrane structure. The relevance of these changes is discussed in relation to sporadic Alzheimer’s disease.