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| Verfasst von: | Nazarenko, Irina [VerfasserIn]  |
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| | Rana, Sanyukta [VerfasserIn] |
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| | Baumann, Alexandra [VerfasserIn] |
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| | McAlear, Jessica [VerfasserIn] |
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| | Hellwig, Andrea [VerfasserIn] |
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| | Trendelenburg, Michael [VerfasserIn] |
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| | Lochnit, Günter [VerfasserIn] |
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| | Preissner, Klaus T. [VerfasserIn] |
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| | Zöller, Margot [VerfasserIn] |
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| Titel: | Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation |
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| Verf.angabe: | Irina Nazarenko, Sanyukta Rana, Alexandra Baumann, Jessica McAlear, Andrea Hellwig, Michael Trendelenburg, Günter Lochnit, Klaus T. Preissner, and Margot Zöller |
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| E-Jahr: | 2010 |
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| Jahr: | 2/2/10 |
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| Umfang: | 11 S. |
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| Fussnoten: | Gesehen am 08.05.2023 |
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| Titel Quelle: | Enthalten in: Cancer research |
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| Ort Quelle: | Philadelphia, Pa. : AACR, 1916 |
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| Jahr Quelle: | 2010 |
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| Band/Heft Quelle: | 70(2010), 4 vom: 14. Feb., Seite 1668-1678 |
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| ISSN Quelle: | 1538-7445 |
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| Abstract: | Tumor-derived exosomes containing the tetraspanin Tspan8 can efficiently induce angiogenesis in tumors and tumor-free tissues. However, little information exists on exosome-endothelial cell (EC) interactions or the proangiogenic role of tetraspanins, which are a constitutive component of exosomes. In this study, we used a rat adenocarcinoma model (AS-Tspan8) to explore the effects of exosomal Tspan8 on angiogenesis. Tspan8 contributed to a selective recruitment of proteins and mRNA into exosomes, including CD106 and CD49d, which were implicated in exosome-EC binding and EC internalization. We found that EC internalized Tspan8-CD49d complex-containing exosomes. Exosome uptake induced vascular endothelial growth factor (VEGF)-independent regulation of several angiogenesis-related genes, including von Willebrand factor, Tspan8, chemokines CXCL5 and MIF, chemokine receptor CCR1, and, together with VEGF, VEGF receptor 2. EC uptake of Tspan8-CD49d complex-containing exosomes was accompanied by enhanced EC proliferation, migration, sprouting, and maturation of EC progenitors. Unraveling these new pathways of exosome-initiated EC regulation could provide new options for therapeutic interference with tumor-induced angiogenesis. Cancer Res; 70(4); 1668-78 |
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| DOI: | doi:10.1158/0008-5472.CAN-09-2470 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1158/0008-5472.CAN-09-2470 |
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| | DOI: https://doi.org/10.1158/0008-5472.CAN-09-2470 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1844746534 |
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| Verknüpfungen: | → Zeitschrift |
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Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation / Nazarenko, Irina [VerfasserIn]; 2/2/10 (Online-Ressource)
