| |  Online-Ressource |
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| Verfasst von: | Preissner, Saskia [VerfasserIn]  |
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| | Kroll, Katharina [VerfasserIn] |
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| | Dunkel, Mathias [VerfasserIn] |
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| | Senger, Christian [VerfasserIn] |
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| | Goldsobel, Gady [VerfasserIn] |
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| | Kuzman, Daniel [VerfasserIn] |
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| | Guenther, Stefan [VerfasserIn] |
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| | Winnenburg, Rainer [VerfasserIn] |
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| | Schroeder, Michael [VerfasserIn] |
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| | Preissner, Robert [VerfasserIn] |
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| Titel: | SuperCYP |
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| Titelzusatz: | a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions |
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| Verf.angabe: | Saskia Preissner, Katharina Kroll, Mathias Dunkel, Christian Senger, Gady Goldsobel, Daniel Kuzman, Stefan Guenther, Rainer Winnenburg, Michael Schroeder and Robert Preissner |
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| E-Jahr: | 2010 |
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| Jahr: | 1 January 2010 |
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| Umfang: | 7 S. |
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| Fussnoten: | Online veröffentlicht 24. November 2009 ; Gesehen am 08.05.2023 |
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| Titel Quelle: | Enthalten in: Nucleic acids research |
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| Ort Quelle: | Oxford : Oxford Univ. Press, 1974 |
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| Jahr Quelle: | 2010 |
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| Band/Heft Quelle: | 38(2010), suppl_1$m1, Seite D237-D243 |
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| ISSN Quelle: | 1362-4962 |
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| Abstract: | Much of the information on the Cytochrome P450 enzymes (CYPs) is spread across literature and the internet. Aggregating knowledge about CYPs into one database makes the search more efficient. Text mining on 57 CYPs and drugs led to a mass of papers, which were screened manually for facts about metabolism, SNPs and their effects on drug degradation. Information was put into a database, which enables the user not only to look up a particular CYP and all metabolized drugs, but also to check tolerability of drug-cocktails and to find alternative combinations, to use metabolic pathways more efficiently. The SuperCYP database contains 1170 drugs with more than 3800 interactions including references. Approximately 2000 SNPs and mutations are listed and ordered according to their effect on expression and/or activity. SuperCYP (http://bioinformatics.charite.de/supercyp) is a comprehensive resource focused on CYPs and drug metabolism. Homology-modeled structures of the CYPs can be downloaded in PDB format and related drugs are available as MOL-files. Within the resource, CYPs can be aligned with each other, drug-cocktails can be ‘mixed’, SNPs, protein point mutations, and their effects can be viewed and corresponding PubMed IDs are given. SuperCYP is meant to be a platform and a starting point for scientists and health professionals for furthering their research. |
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| DOI: | doi:10.1093/nar/gkp970 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1093/nar/gkp970 |
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| | DOI: https://doi.org/10.1093/nar/gkp970 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1844748782 |
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| Verknüpfungen: | → Zeitschrift |
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