Status: Bibliographieeintrag
Standort: ---
Exemplare:
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| Online-Ressource |
Verfasst von: | Leibfried, Andrea [VerfasserIn]  |
| Fricke, Robert Patrick [VerfasserIn]  |
| Morgan, Matthew J. [VerfasserIn]  |
| Bogdan, Sven [VerfasserIn]  |
| Bellaïche, Yohanns [VerfasserIn]  |
Titel: | Drosophila Cip4 and WASp define a branch of the Cdc42-Par6-aPKC pathway regulating E-Cadherin endocytosis |
Verf.angabe: | Andrea Leibfried, Robert Fricke, Matthew J. Morgan, Sven Bogdan, and Yohanns Bellaiche |
E-Jahr: | 2008 |
Jahr: | November 2008 |
Umfang: | 10 S. |
Fussnoten: | Gesehen am 08.05.2023 |
Titel Quelle: | Enthalten in: Current biology |
Ort Quelle: | London : Current Biology Ltd., 1991 |
Jahr Quelle: | 2008 |
Band/Heft Quelle: | 18(2008), 21 vom: Nov., Seite 1639-1648 |
ISSN Quelle: | 1879-0445 |
Abstract: | Background - Integral to the function and morphology of the epithelium is the lattice of cell-cell junctions known as adherens junctions (AJs). AJ stability and plasticity relies on E-Cadherin exocytosis and endocytosis. A mechanism regulating E-Cadherin (E-Cad) exocytosis to the AJs has implicated proteins of the exocyst complex, but mechanisms regulating E-Cad endocytosis from the AJs remain less well understood. - Results - Here we show that Cdc42, Par6, or aPKC loss of function is accompanied by the accumulation of apical E-Cad intracellular punctate structures and the disruption of AJs in Drosophila epithelial cells. These punctate structures derive from large and malformed endocytic vesicles that emanate from the AJs; a phenotype that is also observed upon blocking vesicle scission in dynamin mutant cells. We demonstrate that the Drosophila Cdc42-interacting protein 4 (Cip4) is a Cdc42 effector that interacts with Dynamin and the Arp2/3 activator WASp in Drosophila. Accordingly, Cip4, WASp, or Arp2/3 loss of function also results in defective E-Cadherin endocytosis. - Conclusion - Altogether our results show that Cdc42 functions with Par6 and aPKC to regulate E-Cad endocytosis and define Cip4 and WASp as regulators of the early E-Cad endocytic events in epithelial tissue. |
DOI: | doi:10.1016/j.cub.2008.09.063 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.cub.2008.09.063 |
| Volltext: https://www.sciencedirect.com/science/article/pii/S0960982208013419 |
| DOI: https://doi.org/10.1016/j.cub.2008.09.063 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | CELLBIO |
| DEVBIO |
K10plus-PPN: | 1844751155 |
Verknüpfungen: | → Zeitschrift |
Drosophila Cip4 and WASp define a branch of the Cdc42-Par6-aPKC pathway regulating E-Cadherin endocytosis / Leibfried, Andrea [VerfasserIn]; November 2008 (Online-Ressource)
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