Body mass index interacts with sex to predict readmission in in-patients with alcohol use disorder

• Verfasst von: Hoffmann, Sabine [VerfasserIn]
• Verfasst von: Gerhardt, Sarah [VerfasserIn]
• Verfasst von: Koopmann, Anne [VerfasserIn]
• Verfasst von: Bach, Patrick [VerfasserIn]
• Verfasst von: Sommer, Wolfgang H. [VerfasserIn]
• Verfasst von: Kiefer, Falk [VerfasserIn]
• Verfasst von: Mazza, Massimiliano [VerfasserIn]
• Verfasst von: Lenz, Bernd [VerfasserIn]
• Titel: Body mass index interacts with sex to predict readmission in in-patients with alcohol use disorder
• Verf.angabe: Sabine Hoffmann, Sarah Gerhardt, Anne Koopmann, Patrick Bach, Wolfgang H. Sommer, Falk Kiefer, Massimiliano Mazza, Bernd Lenz
• E-Jahr: 2023
• Jahr: January 2023
• Umfang: 8 S.
• Fussnoten: First published: 02 November 2022 ; Gesehen am 08.05.2023
• Titel Quelle: Enthalten in: Addiction biology
• Ort Quelle: Hoboken, NJ [u.a.] : Wiley-Blackwell, 1996
• Jahr Quelle: 2023
• Band/Heft Quelle: 28(2023), 1, Artikel-ID e13239, Seite 1-8
• ISSN Quelle: 1369-1600
• DOI: doi:10.1111/adb.13239
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: alcohol use disorder
• Sach-SW: body mass index
• Sach-SW: sex-sensitive medicine
• K10plus-PPN: 1844808130

Abstract

A previous highly controlled pilot study revealed that body mass index (BMI) predicts outcome of in-patients with alcohol use disorder (AUD) in a sex-specific manner. We here provide translational evidence from a daily clinical routine setting and investigated whether BMI and sex interact to predict 24-month readmission risk in four naturalistic cohorts of a specialized addiction clinic (i.e., all patients admitted to the clinic from 2016 to 2020): (i) in-patients (443 males and 197 females) and (ii) day clinic patients (241 males and 103 females) with a primary diagnosis of AUD; (iii) in-patients (175 males and 98 females) and (iv) day clinic patients (174 males and 64 females) with a primary substance use disorder (SUD) other than alcohol. In the in-patients with AUD, BMI interacted with sex to predict the 24-month readmission risks (p = 0.008; after adjustment for age and liver enzyme activities: p = 0.012); with higher BMI, the risk increases significantly in males, whereas for females, the risk tends to decrease. In the group of overweight in-patients, we found higher readmission rates in males relative to females with an odds ratio of 1.8 (p = 0.038). No such significant effects were found in the other cohorts. This study's findings support previous results, suggesting that the easily accessible BMI may serve as a predictive and sex-sensitive biomarker for outcome in in-patients with AUD. Future studies are necessary to elucidate the underlying aetiopathological mechanisms.