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| Verfasst von: | Rocca, Maria Assunta [VerfasserIn]  |
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| | Valsasina, Paola [VerfasserIn] |
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| | Meani, Alessandro [VerfasserIn] |
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| | Gobbi, Claudio [VerfasserIn] |
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| | Zecca, Chiara [VerfasserIn] |
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| | Barkhof, Frederik [VerfasserIn] |
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| | Schoonheim, Menno M. [VerfasserIn] |
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| | Strijbis, Eva M. [VerfasserIn] |
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| | Vrenken, Hugo [VerfasserIn] |
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| | Gallo, Antonio [VerfasserIn] |
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| | Bisecco, Alvino [VerfasserIn] |
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| | Ciccarelli, Olga [VerfasserIn] |
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| | Yiannakas, Marios [VerfasserIn] |
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| | Rovira, Alex [VerfasserIn] |
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| | Sastre-Garriga, Jaume [VerfasserIn] |
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| | Palace, Jacqueline [VerfasserIn] |
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| | Matthews, Lucy [VerfasserIn] |
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| | Gass, Achim [VerfasserIn] |
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| | Eisele, Philipp [VerfasserIn] |
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| | Lukas, Carsten [VerfasserIn] |
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| | Bellenberg, Barbara [VerfasserIn] |
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| | Margoni, Monica [VerfasserIn] |
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| | Preziosa, Paolo [VerfasserIn] |
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| | Filippi, Massimo [VerfasserIn] |
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| Titel: | Spinal cord lesions and brain grey matter atrophy independently predict clinical worsening in definite multiple sclerosis |
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| Titelzusatz: | a 5-year, multicentre study : multiple sclerosis : original research |
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| Verf.angabe: | Maria A Rocca, Paola Valsasina, Alessandro Meani, Claudio Gobbi, Chiara Zecca, Frederik Barkhof, Menno M Schoonheim, Eva M Strijbis, Hugo Vrenken, Antonio Gallo, Alvino Bisecco, Olga Ciccarelli, Marios Yiannakas, Alex Rovira, Jaume Sastre-Garriga, Jacqueline Palace, Lucy Matthews, Achim Gass, Philipp Eisele, Carsten Lukas, Barbara Bellenberg, Monica Margoni, Paolo Preziosa, Massimo Filippi, on behalf of MAGNIMS study group |
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| Jahr: | 2023 |
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| Umfang: | 9 S. |
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| Fussnoten: | Online veröffentlicht: 28. September 2022 ; Gesehen am 09.05.2023 |
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| Titel Quelle: | Enthalten in: Journal of neurology, neurosurgery, and psychiatry |
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| Ort Quelle: | London : BMJ Publishing Group, 1944 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 94(2023), Seite 10-18 |
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| ISSN Quelle: | 1468-330X |
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| Abstract: | Objectives To evaluate the combined contribution of brain and cervical cord damage in predicting 5-year clinical worsening in a multicentre cohort of definite multiple sclerosis (MS) patients. Methods Baseline 3.0T brain and cervical cord T2-weighted and three-dimensional T1-weighted MRI was acquired in 367 patients with MS (326 relapse-onset and 41 progressive-onset) and 179 healthy controls. Expanded Disability Status Scale (EDSS) score was obtained at baseline and after a median follow-up of 5.1 years (IQR=4.8-5.2). At follow-up, patients were classified as clinically stable/worsened according to EDSS changes. Generalised linear mixed models identified predictors of clinical worsening, evolution to secondary progressive (SP) MS and reaching EDSS=3.0, 4.0 and 6.0 milestones at 5 years. Results At follow-up, 120/367 (33%) patients with MS worsened clinically; 36/256 (14%) patients with relapsing-remitting evolved to SPMS. Baseline predictors of EDSS worsening were progressive-onset versus relapse-onset MS (standardised beta (beta)=0.97), higher EDSS (beta=0.41), higher cord lesion number (beta=0.41), lower normalised cortical volume (beta=-0.15) and lower cord area (beta=-0.28) (C-index=0.81). Older age (beta=0.86), higher EDSS (beta=1.40) and cord lesion number (beta=0.87) independently predicted SPMS conversion (C-index=0.91). Predictors of reaching EDSS=3.0 after 5 years were higher baseline EDSS (beta=1.49), cord lesion number (beta=1.02) and lower normalised cortical volume (beta=-0.56) (C-index=0.88). Baseline age (beta=0.30), higher EDSS (beta=2.03), higher cord lesion number (beta=0.66) and lower cord area (beta=-0.41) predicted EDSS=4.0 (C-index=0.92). Finally, higher baseline EDSS (beta=1.87) and cord lesion number (beta=0.54) predicted EDSS=6.0 (C-index=0.91). Conclusions Spinal cord damage and, to a lesser extent, cortical volume loss helped predicting worse 5-year clinical outcomes in MS. |
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| DOI: | doi:10.1136/jnnp-2022-329854 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1136/jnnp-2022-329854 |
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| | kostenfrei: Volltext: http://jnnp.bmj.com/content/94/1/10 |
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| | DOI: https://doi.org/10.1136/jnnp-2022-329854 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | damage |
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| | diagnosis |
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| | disability progression |
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| | impairment |
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| | mri |
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| | ms |
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| | multiple sclerosis |
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| | relapse-onset |
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| | volume loss |
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| K10plus-PPN: | 1844867269 |
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| Verknüpfungen: | → Zeitschrift |
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Spinal cord lesions and brain grey matter atrophy independently predict clinical worsening in definite multiple sclerosis / Rocca, Maria Assunta [VerfasserIn]; 2023 (Online-Ressource)
