Influence of HPV16 E2 and its localisation on the expression of matrix metalloproteinase-9

• Verfasst von: Mühlen, Sabrina [VerfasserIn]
• Verfasst von: Behren, Andreas [VerfasserIn]
• Verfasst von: Iftner, Thomas [VerfasserIn]
• Verfasst von: Simon, Christian [VerfasserIn]
• Titel: Influence of HPV16 E2 and its localisation on the expression of matrix metalloproteinase-9
• Verf.angabe: Sabrina Mühlen, Andreas Behren, Thomas Iftner and Christian Simon
• E-Jahr: 2010
• Jahr: August 1, 2010
• Umfang: 9 S.
• Fussnoten: Gesehen am 10.05.2023
• Titel Quelle: Enthalten in: International journal of oncology
• Ort Quelle: Athens : Spandidos Publ., 2001
• Jahr Quelle: 2010
• Band/Heft Quelle: 37(2010), 2, Seite 337-345
• ISSN Quelle: 1791-2423
• DOI: doi:10.3892/ijo_00000682
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1844953580

Abstract

Infection with the high-risk HPV types 16 and 18 is the major cause of cervical cancer and plays a role in the development of certain head and neck and skin cancers. We have previously demonstrated that the Early Protein 2 of the Cottontail Rabbit papillomavirus (CRPV), required for skin carcinogenesis in a rabbit model, is able to induce the expression of a matrix metalloproteinase (MMP-9); a protease known to play a key role in invasion and metastasis. However, as of now we do not understand the underlying mechanism of activation nor relevance for the human system. Here, we report that high-risk human papillomavirus HPV16 E2 similar to our previously reported results on CRPV E2 activates the human MMP-9 promoter predominantly via the MEK1-ERK1/2-AP-1-signaling pathway. In addition this activation is associated with a nuclear sub-localisation of HPV16-E2 suggesting a nuclear protein-protein or protein-DNA interaction of E2 as the underlying mechanism of activation.