Invasion of mosquito salivary glands by malaria parasites

• Verfasst von: Müller, Ann-Kristin [VerfasserIn]
• Verfasst von: Kohlhepp, Florian [VerfasserIn]
• Verfasst von: Hammerschmidt-Kamper, Christiane [VerfasserIn]
• Verfasst von: Michel, Kristin [VerfasserIn]
• Titel: Invasion of mosquito salivary glands by malaria parasites
• Titelzusatz: prerequisites and defense strategies
• Verf.angabe: Ann-Kristin Mueller, Florian Kohlhepp, Christiane Hammerschmidt, Kristin Michel
• E-Jahr: 2010
• Jahr: 8 June 2010
• Umfang: 7 S.
• Fussnoten: Gesehen am 10.05.2023
• Titel Quelle: Enthalten in: International journal for parasitology
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1971
• Jahr Quelle: 2010
• Band/Heft Quelle: 40(2010), 11 vom: Sept., Seite 1229-1235
• ISSN Quelle: 1879-0135
• DOI: doi:10.1016/j.ijpara.2010.05.005
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Malaria
• Sach-SW: Parasite-vector interactions
• Sach-SW: Vector-borne diseases
• K10plus-PPN: 1844956113

Abstract

The interplay between vector and pathogen is essential for vector-borne disease transmission. Dissecting the molecular basis of refractoriness of some vectors may pave the way to novel disease control mechanisms. A pathogen often needs to overcome several physical barriers, such as the peritrophic matrix, midgut epithelium and salivary glands. Additionally, the arthropod vector elicites immune responses that can severely limit transmission success. One important step in the transmission of most vector-borne diseases is the entry of the disease agent into the salivary glands of its arthropod vector. The salivary glands of blood-feeding arthropods produce a complex mixture of molecules that facilitate blood feeding by inhibition of the host haemostasis, inflammation and immune reactions. Pathogen entry into salivary glands is a receptor-mediated process, which requires molecules on the surface of the pathogen and salivary gland. In most cases, the nature of these molecules remains unknown. Recent advances in our understanding of malaria parasite entry into mosquito salivary glands strongly suggests that specific carbohydrate molecules on the salivary gland surface function as docking receptors for malaria parasites.