| Online-Ressource |
Verfasst von: | Rahbari, Nuh Nabi [VerfasserIn]  |
| Aigner, Maximilian [VerfasserIn]  |
| Thorlund, Kristian [VerfasserIn]  |
| Mollberg, Nathan [VerfasserIn]  |
| Motschall, Edith [VerfasserIn]  |
| Jensen, Katrin [VerfasserIn]  |
| Diener, Markus K. [VerfasserIn]  |
| Büchler, Markus W. [VerfasserIn]  |
| Koch, Moritz [VerfasserIn]  |
| Weitz, Jürgen [VerfasserIn]  |
Titel: | Meta-analysis shows that detection of circulating tumor cells indicates poor prognosis in patients with colorectal cancer |
Verf.angabe: | Nuh N. Rahbari, Maximilian Aigner, Kristian Thorlund, Nathan Mollberg, Edith Motschall, Katrin Jensen, Markus K. Diener, Markus W. Büchler, Moritz Koch, and Jürgen Weitz |
E-Jahr: | 2010 |
Jahr: | 25 January 2010 |
Umfang: | 26 S. |
Fussnoten: | Gesehen am 10.05.2023 |
Titel Quelle: | Enthalten in: Gastroenterology |
Ort Quelle: | New York, NY : Elsevier, 1949 |
Jahr Quelle: | 2010 |
Band/Heft Quelle: | 138(2010), 5, Seite 1714-1726.e13 |
ISSN Quelle: | 1528-0012 |
Abstract: | Background & Aims - The prognostic significance of circulating (CTCs) and disseminated tumor cells in patients with colorectal cancer (CRC) is controversial. We performed a meta-analysis of available studies to assess whether the detection of tumor cells in the blood and bone marrow (BM) of patients diagnosed with primary CRC can be used as a prognostic factor. - Methods - We searched the Medline, Biosis, Science Citation Index, and Embase databases and reference lists of relevant articles (including review articles) for studies that assessed the prognostic relevance of tumor cell detection in the peripheral blood (PB), mesenteric/portal blood (MPB), or BM of patients with CRC. Meta-analyses were performed using a random effects model, with hazard ratio (HR) and 95% confidence intervals (95% CIs) as effect measures. - Results - A total of 36 studies, including 3094 patients, were eligible for final analyses. Pooled analyses that combined all sampling sites (PB, MPB, and BM) associated the detection of tumor cells with poor recurrence-free survival (RFS) (HR = 3.24 [95% CI: 2.06-5.10], n = 26, I2 = 77%) and overall survival (OS) (2.28 [1.55-3.38], n = 21, I2 = 66%). Stratification by sampling site showed that detection of tumor cells in the PB compartment was a statistically significant prognostic factor (RFS: 3.06 [1.74-5.38], n = 19, I2 = 78%; OS: 2.70 [1.74-4.20], n = 16, I2 = 59%) but not in the MPB (RFS: 4.12 [1.01-16.83], n = 8, I2 = 75%; OS: 4.80 [0.81-28.32], n = 5, I2 = 82%) or in the BM (RFS: 2.17 [0.94-5.03], n = 4, I2 = 78%; OS: 1.50 [0.52-4.32], n = 3, I2 = 84%). - Conclusion - Detection of CTCs in the PB indicates poor prognosis in patients with primary CRC. |
DOI: | doi:10.1053/j.gastro.2010.01.008 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1053/j.gastro.2010.01.008 |
| Volltext: https://www.sciencedirect.com/science/article/pii/S0016508510000454 |
| DOI: https://doi.org/10.1053/j.gastro.2010.01.008 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Circulating Tumor Cells |
| Colorectal Cancer |
| Prognosis |
K10plus-PPN: | 1844956199 |
Verknüpfungen: | → Zeitschrift |
Meta-analysis shows that detection of circulating tumor cells indicates poor prognosis in patients with colorectal cancer / Rahbari, Nuh Nabi [VerfasserIn]; 25 January 2010 (Online-Ressource)