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Verfasst von:Rahbari, Nuh Nabi [VerfasserIn]   i
 Aigner, Maximilian [VerfasserIn]   i
 Thorlund, Kristian [VerfasserIn]   i
 Mollberg, Nathan [VerfasserIn]   i
 Motschall, Edith [VerfasserIn]   i
 Jensen, Katrin [VerfasserIn]   i
 Diener, Markus K. [VerfasserIn]   i
 Büchler, Markus W. [VerfasserIn]   i
 Koch, Moritz [VerfasserIn]   i
 Weitz, Jürgen [VerfasserIn]   i
Titel:Meta-analysis shows that detection of circulating tumor cells indicates poor prognosis in patients with colorectal cancer
Verf.angabe:Nuh N. Rahbari, Maximilian Aigner, Kristian Thorlund, Nathan Mollberg, Edith Motschall, Katrin Jensen, Markus K. Diener, Markus W. Büchler, Moritz Koch, and Jürgen Weitz
E-Jahr:2010
Jahr:25 January 2010
Umfang:26 S.
Fussnoten:Gesehen am 10.05.2023
Titel Quelle:Enthalten in: Gastroenterology
Ort Quelle:New York, NY : Elsevier, 1949
Jahr Quelle:2010
Band/Heft Quelle:138(2010), 5, Seite 1714-1726.e13
ISSN Quelle:1528-0012
Abstract:Background & Aims - The prognostic significance of circulating (CTCs) and disseminated tumor cells in patients with colorectal cancer (CRC) is controversial. We performed a meta-analysis of available studies to assess whether the detection of tumor cells in the blood and bone marrow (BM) of patients diagnosed with primary CRC can be used as a prognostic factor. - Methods - We searched the Medline, Biosis, Science Citation Index, and Embase databases and reference lists of relevant articles (including review articles) for studies that assessed the prognostic relevance of tumor cell detection in the peripheral blood (PB), mesenteric/portal blood (MPB), or BM of patients with CRC. Meta-analyses were performed using a random effects model, with hazard ratio (HR) and 95% confidence intervals (95% CIs) as effect measures. - Results - A total of 36 studies, including 3094 patients, were eligible for final analyses. Pooled analyses that combined all sampling sites (PB, MPB, and BM) associated the detection of tumor cells with poor recurrence-free survival (RFS) (HR = 3.24 [95% CI: 2.06-5.10], n = 26, I2 = 77%) and overall survival (OS) (2.28 [1.55-3.38], n = 21, I2 = 66%). Stratification by sampling site showed that detection of tumor cells in the PB compartment was a statistically significant prognostic factor (RFS: 3.06 [1.74-5.38], n = 19, I2 = 78%; OS: 2.70 [1.74-4.20], n = 16, I2 = 59%) but not in the MPB (RFS: 4.12 [1.01-16.83], n = 8, I2 = 75%; OS: 4.80 [0.81-28.32], n = 5, I2 = 82%) or in the BM (RFS: 2.17 [0.94-5.03], n = 4, I2 = 78%; OS: 1.50 [0.52-4.32], n = 3, I2 = 84%). - Conclusion - Detection of CTCs in the PB indicates poor prognosis in patients with primary CRC.
DOI:doi:10.1053/j.gastro.2010.01.008
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1053/j.gastro.2010.01.008
 Volltext: https://www.sciencedirect.com/science/article/pii/S0016508510000454
 DOI: https://doi.org/10.1053/j.gastro.2010.01.008
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Circulating Tumor Cells
 Colorectal Cancer
 Prognosis
K10plus-PPN:1844956199
Verknüpfungen:→ Zeitschrift

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