Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Hildenbrand, Maike [VerfasserIn]   i
 Rhiemeier, Verena Margrit [VerfasserIn]   i
 Hartenstein, Bettina [VerfasserIn]   i
 Lahrmann, Bernd [VerfasserIn]   i
 Grabe, Niels [VerfasserIn]   i
 Angel, Peter [VerfasserIn]   i
 Heß, Jochen [VerfasserIn]   i
Titel:Impaired skin regeneration and remodeling after cutaneous injury and chemically induced hyperplasia in taps-transgenic mice
Verf.angabe:Maike Hildenbrand, Verena Rhiemeier, Bettina Hartenstein, Bernd Lahrmann, Niels Grabe, Peter Angel and Jochen Hess
E-Jahr:2010
Jahr:[July 2010]
Umfang:9 S.
Fussnoten:Gesehen am 10.05.2023
Titel Quelle:Enthalten in: The journal of investigative dermatology
Ort Quelle:Amsterdam : Elsevier, 1938
Jahr Quelle:2010
Band/Heft Quelle:130(2010), 7 vom: Juli, Seite 1922-1930
ISSN Quelle:1523-1747
Abstract:Recently, we identified an AP-1-dependent target gene in 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated mouse back skin, which encodes a retroviral-like aspartic proteinase (Taps/Asprv1). Taps expression was detected almost exclusively in stratified epithelia of mouse embryos and adult tissues, and enhanced protein levels were present in several non-neoplastic human skin disorders, implicating a crucial role for differentiation and homeostasis of multilayered epithelia. Here, we generated a mouse model in which Taps transgene expression is under the control of the human ubiquitin C promoter (UBC-Taps). Although no obvious phenotype was observed in normal skin development and homeostasis, these mice showed a significant delay in cutaneous wound closure compared with control animals. Shortly after re-epithelialization, we found an increase in keratinocytes in the stratum granulosum, which express Filaggrin, a late differentiation marker. A hypergranulosum-like phenotype with increased numbers of Filaggrin-positive keratinocytes was also observed in UBC-Taps mice after administration of TPA. In summary, these data show that aberrant Taps expression causes impaired skin regeneration and skin remodeling after cutaneous injury and chemically induced hyperplasia.
DOI:doi:10.1038/jid.2010.54
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1038/jid.2010.54
 Volltext: https://www.sciencedirect.com/science/article/pii/S0022202X15349149
 DOI: https://doi.org/10.1038/jid.2010.54
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1844963616
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/69074117   QR-Code
zum Seitenanfang