| Online-Ressource |
Verfasst von: | Hildenbrand, Maike [VerfasserIn]  |
| Rhiemeier, Verena Margrit [VerfasserIn]  |
| Hartenstein, Bettina [VerfasserIn]  |
| Lahrmann, Bernd [VerfasserIn]  |
| Grabe, Niels [VerfasserIn]  |
| Angel, Peter [VerfasserIn]  |
| Heß, Jochen [VerfasserIn]  |
Titel: | Impaired skin regeneration and remodeling after cutaneous injury and chemically induced hyperplasia in taps-transgenic mice |
Verf.angabe: | Maike Hildenbrand, Verena Rhiemeier, Bettina Hartenstein, Bernd Lahrmann, Niels Grabe, Peter Angel and Jochen Hess |
E-Jahr: | 2010 |
Jahr: | [July 2010] |
Umfang: | 9 S. |
Fussnoten: | Gesehen am 10.05.2023 |
Titel Quelle: | Enthalten in: The journal of investigative dermatology |
Ort Quelle: | Amsterdam : Elsevier, 1938 |
Jahr Quelle: | 2010 |
Band/Heft Quelle: | 130(2010), 7 vom: Juli, Seite 1922-1930 |
ISSN Quelle: | 1523-1747 |
Abstract: | Recently, we identified an AP-1-dependent target gene in 12-O-tetradecanoylphorbol-13-acetate (TPA)-treated mouse back skin, which encodes a retroviral-like aspartic proteinase (Taps/Asprv1). Taps expression was detected almost exclusively in stratified epithelia of mouse embryos and adult tissues, and enhanced protein levels were present in several non-neoplastic human skin disorders, implicating a crucial role for differentiation and homeostasis of multilayered epithelia. Here, we generated a mouse model in which Taps transgene expression is under the control of the human ubiquitin C promoter (UBC-Taps). Although no obvious phenotype was observed in normal skin development and homeostasis, these mice showed a significant delay in cutaneous wound closure compared with control animals. Shortly after re-epithelialization, we found an increase in keratinocytes in the stratum granulosum, which express Filaggrin, a late differentiation marker. A hypergranulosum-like phenotype with increased numbers of Filaggrin-positive keratinocytes was also observed in UBC-Taps mice after administration of TPA. In summary, these data show that aberrant Taps expression causes impaired skin regeneration and skin remodeling after cutaneous injury and chemically induced hyperplasia. |
DOI: | doi:10.1038/jid.2010.54 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1038/jid.2010.54 |
| Volltext: https://www.sciencedirect.com/science/article/pii/S0022202X15349149 |
| DOI: https://doi.org/10.1038/jid.2010.54 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1844963616 |
Verknüpfungen: | → Zeitschrift |
Impaired skin regeneration and remodeling after cutaneous injury and chemically induced hyperplasia in taps-transgenic mice / Hildenbrand, Maike [VerfasserIn]; [July 2010] (Online-Ressource)