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Verfasst von:Comba, Peter [VerfasserIn]   i
 Dovalil, Nina [VerfasserIn]   i
 Haberhauer, Gebhard [VerfasserIn]   i
 Hanson, Graeme R. [VerfasserIn]   i
 Kato, Yuki [VerfasserIn]   i
 Taura, Toshiaki [VerfasserIn]   i
Titel:Complex formation and stability of westiellamide derivatives with copper(II)
Verf.angabe:Peter Comba, Nina Dovalil, Gebhard Haberhauer, Graeme R. Hanson, Yuki Kato, Toshiaki Taura
E-Jahr:2010
Jahr:21 May 2010
Umfang:7 S.
Fussnoten:Gesehen am 10.05.2023
Titel Quelle:Enthalten in: Journal of biological inorganic chemistry
Ort Quelle:Berlin : Springer, 1996
Jahr Quelle:2010
Band/Heft Quelle:15(2010), 7 vom: Sept., Seite 1129-1135
ISSN Quelle:1432-1327
Abstract:The CuII coordination chemistry of three synthetic analogues of westiellamide (H3Lwa) with an [18]azacrown-6 macrocyclic structure and imidazole (H3L1), oxazole (H3L2), or thiazole (H3L3) heterocyclic donors in addition to the peptide groups, is reported. The Nheterocycle-Npeptide-Nheterocycle binding sites are highly preorganized for the coordination to CuII ions. The stability constants of mono- and dinuclear CuII complexes of H3L1, H3L2, and H3L3, obtained by isothermal titration microcalorimetry, are reported. EPR and NMR spectroscopy as well as electrospray ionization mass spectrometry (ESI-MS) were used to characterize the complexes formed in solution. The stabilities of the mononuclear and dinuclear CuII complexes of the three ligands are in the range of 105 M−1, but there are subtle differences; specifically the oxazole-derived ligand has, in contrast to the other two macrocycles, a negative formation entropy for coordination to the first CuII ion and a higher stability for complexation to a second CuII center in comparison with the first CuII center (cooperativity). Differences between the three ligands are also apparent in terms of the formation mechanism. With the oxazole-based ligand H3L2, NMR spectroscopy, EPR spectroscopy, and ESI-MS indicate the formation of a ligand-CuII 2:1 intermediate, and this may explain the differences in the formation entropy as well as the cooperativity.
DOI:doi:10.1007/s00775-010-0673-7
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1007/s00775-010-0673-7
 DOI: https://doi.org/10.1007/s00775-010-0673-7
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Complex formation
 Cyclic peptides
 Spectroscopy
 Stability constants
 Westiellamide
K10plus-PPN:1845053672
Verknüpfungen:→ Zeitschrift

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