Pattern-based sensing of sulfated glycosaminoglycans with a dynamic mixture of iron complexes

• Verfasst von: Müller-Graff, Peter-Korbinian Benedikt Christian [VerfasserIn]
• Verfasst von: Szelke, Helga [VerfasserIn]
• Verfasst von: Severin, Kay [VerfasserIn]
• Verfasst von: Krämer, Roland [VerfasserIn]
• Titel: Pattern-based sensing of sulfated glycosaminoglycans with a dynamic mixture of iron complexes
• Verf.angabe: Peter-Korbinian Müller-Graff, Helga Szelke, Kay Severin, and Roland Krämer
• E-Jahr: 2010
• Jahr: 2nd March 2010
• Umfang: 5 S.
• Fussnoten: First published as an Advance Article on the web 2nd March 2010 ; Gesehen am 11.05.2023
• Titel Quelle: Enthalten in: Organic & biomolecular chemistry
• Ort Quelle: Cambridge : Royal Society of Chemistry, 2003
• Jahr Quelle: 2010
• Band/Heft Quelle: 8(2010), 10, Seite 2327-2331
• ISSN Quelle: 1477-0539
• DOI: doi:10.1039/C000420K
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1845189183

Abstract

A dynamic mixture of iron complexes was used as a colorimetric sensor for sulfated glycosaminoglycans. The sensing ensemble was prepared by mixing [FeCl2(H2O)4] with dipicolylamine, the functionalized bipyridyl ligand N-(6-aminohexyl)-4′-methyl-2,2′-bipyridine-4-carboxamide, and the dye Evans Blue. Upon addition of the analytes, characteristic changes in the UV-Vis spectrum of the solutions were observed. The spectral changes allowed identifying different sulfated glucosaminoglycans (unfractionated heparin, low molecular weight heparin, dextran sulfate, chondroitin sulfate A, dermatan sulfate, heparan sulfate) with the help of a linear discriminant analysis. Furthermore, it was possible to distinguish mixtures of unfractionated heparin and heparan sulfate with good resolution.