| |  Online-Ressource |
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| Verfasst von: | Wu, Di [VerfasserIn]  |
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| | Baresch, Diego [VerfasserIn] |
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| | Cook, Colin [VerfasserIn] |
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| | Ma, Zhichao [VerfasserIn] |
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| | Duan, Mengtong [VerfasserIn] |
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| | Malounda, Dina [VerfasserIn] |
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| | Maresca, David [VerfasserIn] |
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| | Abundo, Maria P. [VerfasserIn] |
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| | Lee, Justin [VerfasserIn] |
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| | Shivaei, Shirin [VerfasserIn] |
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| | Mittelstein, David R. [VerfasserIn] |
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| | Qiu, Tian [VerfasserIn] |
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| | Fischer, Peer [VerfasserIn] |
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| | Shapiro, Mikhail G. [VerfasserIn] |
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| Titel: | Biomolecular actuators for genetically selective acoustic manipulation of cells |
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| Verf.angabe: | Di Wu, Diego Baresch, Colin Cook, Zhichao Ma, Mengtong Duan, Dina Malounda, David Maresca, Maria P. Abundo, Justin Lee, Shirin Shivaei, David R. Mittelstein, Tian Qiu, Peer Fischer, Mikhail G. Shapiro |
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| E-Jahr: | 2023 |
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| Jahr: | 22 February 2023 |
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| Umfang: | 16 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Gesehen am 12.12.2023 |
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| Titel Quelle: | Enthalten in: Science advances |
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| Ort Quelle: | Washington, DC [u.a.] : Assoc., 2015 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 9(2023), 8, Artikel-ID eadd9186, Seite 1-16 |
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| ISSN Quelle: | 2375-2548 |
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| Abstract: | The ability to physically manipulate specific cells is critical for the fields of biomedicine, synthetic biology, and living materials. Ultrasound has the ability to manipulate cells with high spatiotemporal precision via acoustic radiation force (ARF). However, because most cells have similar acoustic properties, this capability is disconnected from cellular genetic programs. Here, we show that gas vesicles (GVs) - a unique class of gas-filled protein nanostructures - can serve as genetically encodable actuators for selective acoustic manipulation. Because of their lower density and higher compressibility relative to water, GVs experience strong ARF with opposite polarity to most other materials. When expressed inside cells, GVs invert the cells’ acoustic contrast and amplify the magnitude of their ARF, allowing the cells to be selectively manipulated with sound waves based on their genotype. GVs provide a direct link between gene expression and acoustomechanical actuation, opening a paradigm for selective cellular control in a broad range of contexts. |
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| DOI: | doi:10.1126/sciadv.add9186 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1126/sciadv.add9186 |
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| | Volltext: https://www.science.org/doi/10.1126/sciadv.add9186 |
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| | DOI: https://doi.org/10.1126/sciadv.add9186 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 184527203X |
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| Verknüpfungen: | → Zeitschrift |
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Biomolecular actuators for genetically selective acoustic manipulation of cells / Wu, Di [VerfasserIn]; 22 February 2023 (Online-Ressource)
