| Online-Ressource |
Verfasst von: | Neumann, Leo [VerfasserIn]  |
| Pforr, Carina [VerfasserIn]  |
| Beaudouin, Joel [VerfasserIn]  |
| Pappa, Alexander [VerfasserIn]  |
| Fricker, Nicolai Benjamin [VerfasserIn]  |
| Krammer, Peter H. [VerfasserIn]  |
| Lavrik, Inna N. [VerfasserIn]  |
| Eils, Roland [VerfasserIn]  |
Titel: | Dynamics within the CD95 death-inducing signaling complex decide life and death of cells |
Verf.angabe: | Leo Neumann, Carina Pforr, Joel Beaudouin, Alexander Pappa, Nicolai Fricker, Peter H Krammer, Inna N Lavrik and Roland Eils |
E-Jahr: | 2010 |
Jahr: | 9 March 2010 |
Umfang: | 17 S. |
Fussnoten: | Gesehen am 12.05.2023 |
Titel Quelle: | Enthalten in: Molecular systems biology |
Ort Quelle: | Heidelberg : EMBO Press, 2005 |
Jahr Quelle: | 2010 |
Band/Heft Quelle: | 6(2010), 1 vom: 1. Jan., Artikel-ID 352, Seite 1-17 |
ISSN Quelle: | 1744-4292 |
Abstract: | This study explores the dilemma in cellular signaling that triggering of CD95 (Fas/APO-1) in some situations results in cell death and in others leads to the activation of NF-?B. We established an integrated kinetic mathematical model for CD95-mediated apoptotic and NF-?B signaling. Systematic model reduction resulted in a surprisingly simple model well approximating experimentally observed dynamics. The model postulates a new link between c-FLIPL cleavage in the death-inducing signaling complex (DISC) and the NF-?B pathway. We validated experimentally that CD95 stimulation resulted in an interaction of p43-FLIP with the IKK complex followed by its activation. Furthermore, we showed that the apoptotic and NF-?B pathways diverge already at the DISC. Model and experimental analysis of DISC formation showed that a subtle balance of c-FLIPL and procaspase-8 determines life/death decisions in a nonlinear manner. We present an integrated model describing the complex dynamics of CD95-mediated apoptosis and NF-?B signaling. |
DOI: | doi:10.1038/msb.2010.6 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1038/msb.2010.6 |
| Volltext: https://www.embopress.org/doi/full/10.1038/msb.2010.6 |
| DOI: https://doi.org/10.1038/msb.2010.6 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | apoptosis |
| CD95 signaling |
| DISC |
| model reduction |
| NF-κB |
K10plus-PPN: | 1845274903 |
Verknüpfungen: | → Zeitschrift |
Dynamics within the CD95 death-inducing signaling complex decide life and death of cells / Neumann, Leo [VerfasserIn]; 9 March 2010 (Online-Ressource)