| |  Online-Ressource |
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| Verfasst von: | Neumann, Leo [VerfasserIn]  |
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| | Pforr, Carina [VerfasserIn] |
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| | Beaudouin, Joel [VerfasserIn] |
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| | Pappa, Alexander [VerfasserIn] |
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| | Fricker, Nicolai Benjamin [VerfasserIn] |
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| | Krammer, Peter H. [VerfasserIn] |
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| | Lavrik, Inna N. [VerfasserIn] |
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| | Eils, Roland [VerfasserIn] |
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| Titel: | Dynamics within the CD95 death-inducing signaling complex decide life and death of cells |
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| Verf.angabe: | Leo Neumann, Carina Pforr, Joel Beaudouin, Alexander Pappa, Nicolai Fricker, Peter H Krammer, Inna N Lavrik and Roland Eils |
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| E-Jahr: | 2010 |
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| Jahr: | 9 March 2010 |
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| Umfang: | 17 S. |
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| Fussnoten: | Gesehen am 12.05.2023 |
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| Titel Quelle: | Enthalten in: Molecular systems biology |
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| Ort Quelle: | Heidelberg : EMBO Press, 2005 |
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| Jahr Quelle: | 2010 |
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| Band/Heft Quelle: | 6(2010), 1 vom: 1. Jan., Artikel-ID 352, Seite 1-17 |
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| ISSN Quelle: | 1744-4292 |
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| Abstract: | This study explores the dilemma in cellular signaling that triggering of CD95 (Fas/APO-1) in some situations results in cell death and in others leads to the activation of NF-?B. We established an integrated kinetic mathematical model for CD95-mediated apoptotic and NF-?B signaling. Systematic model reduction resulted in a surprisingly simple model well approximating experimentally observed dynamics. The model postulates a new link between c-FLIPL cleavage in the death-inducing signaling complex (DISC) and the NF-?B pathway. We validated experimentally that CD95 stimulation resulted in an interaction of p43-FLIP with the IKK complex followed by its activation. Furthermore, we showed that the apoptotic and NF-?B pathways diverge already at the DISC. Model and experimental analysis of DISC formation showed that a subtle balance of c-FLIPL and procaspase-8 determines life/death decisions in a nonlinear manner. We present an integrated model describing the complex dynamics of CD95-mediated apoptosis and NF-?B signaling. |
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| DOI: | doi:10.1038/msb.2010.6 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1038/msb.2010.6 |
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| | Volltext: https://www.embopress.org/doi/full/10.1038/msb.2010.6 |
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| | DOI: https://doi.org/10.1038/msb.2010.6 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | apoptosis |
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| | CD95 signaling |
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| | DISC |
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| | model reduction |
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| | NF-κB |
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| K10plus-PPN: | 1845274903 |
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| Verknüpfungen: | → Zeitschrift |
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Dynamics within the CD95 death-inducing signaling complex decide life and death of cells / Neumann, Leo [VerfasserIn]; 9 March 2010 (Online-Ressource)
