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Verfasst von:Neumann-Pfeifer, Silke [VerfasserIn]   i
 Hansen, Clinton H [VerfasserIn]   i
 Wingreen, Ned S [VerfasserIn]   i
 Sourjik, Victor [VerfasserIn]   i
Titel:Differences in signalling by directly and indirectly binding ligands in bacterial chemotaxis
Verf.angabe:Silke Neumann, Clinton H Hansen, Ned S Wingreen and Victor Sourjik
E-Jahr:2010
Jahr:10 September 2010
Umfang:12 S.
Fussnoten:Gesehen am 12.05.2023
Titel Quelle:Enthalten in: European Molecular Biology OrganizationThe EMBO journal
Ort Quelle:[London] : Nature Publishing Group UK, 1982
Jahr Quelle:2010
Band/Heft Quelle:29(2010), 20 vom: 10. Okt., Seite 3484-3495
ISSN Quelle:1460-2075
Abstract:In chemotaxis of Escherichia coli and other bacteria, extracellular stimuli are perceived by transmembrane receptors that bind their ligands either directly, or indirectly through periplasmic-binding proteins (BPs). As BPs are also involved in ligand uptake, they provide a link between chemotaxis and nutrient utilization by cells. However, signalling by indirectly binding ligands remains much less understood than signalling by directly binding ligands. Here, we compared intracellular responses mediated by both types of ligands and developed a new mathematical model for signalling by indirectly binding ligands. We show that indirect binding allows cells to better control sensitivity to specific ligands in response to their nutrient environment and to coordinate chemotaxis with ligand transport, but at the cost of the dynamic range being much narrower than for directly binding ligands. We further demonstrate that signal integration by the chemosensory complexes does not depend on the type of ligand. Overall, our data suggest that the distinction between signalling by directly and indirectly binding ligands is more physiologically important than the traditional distinction between high- and low-abundance receptors.
DOI:doi:10.1038/emboj.2010.224
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1038/emboj.2010.224
 Volltext: https://www.embopress.org/doi/full/10.1038/emboj.2010.224
 DOI: https://doi.org/10.1038/emboj.2010.224
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:bacterial chemotaxis
 FRET
 signal integration
 signal transduction
 transport
K10plus-PPN:1845283007
Verknüpfungen:→ Zeitschrift

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