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| Verfasst von: | Remppis, Bjoern-Andrew [VerfasserIn]  |
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| | Bea, Florian [VerfasserIn] |
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| | Greten, Henry Johannes [VerfasserIn] |
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| | Buttler, Annette [VerfasserIn] |
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| | Wang, Hongjie [VerfasserIn] |
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| | Zhou, Qianxing [VerfasserIn] |
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| | Preusch, Michael R. [VerfasserIn] |
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| | Enk, Ronny [VerfasserIn] |
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| | Ehehalt, Robert [VerfasserIn] |
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| | Katus, Hugo [VerfasserIn] |
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| | Blessing, Erwin [VerfasserIn] |
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| Titel: | Rhizoma coptidis inhibits LPS-induced MCP-1/CCL2 production in murine macrophages via an AP-1 and NFk B-dependent pathway |
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| Verf.angabe: | Andrew Remppis, Florian Bea, Henry Johannes Greten, Annette Buttler, Hongjie Wang, Qianxing Zhou, Michael R. Preusch, Ronny Enk, Robert Ehehalt, Hugo Katus, and Erwin Blessing |
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| E-Jahr: | 2010 |
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| Jahr: | 21 Jun 2010 |
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| Umfang: | 9 S. |
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| Fussnoten: | Gesehen am 12.05.2023 |
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| Titel Quelle: | Enthalten in: Mediators of inflammation |
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| Ort Quelle: | Sylvania, Ohio : Hindawi Publishing Corp., 1992 |
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| Jahr Quelle: | 2010 |
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| Band/Heft Quelle: | 2010(2010) vom: Juni, Artikel-ID e194896, Seite 1-9 |
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| ISSN Quelle: | 1466-1861 |
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| Abstract: | Introduction. The Chinese extract Rhizoma coptidis is well known for its anti-inflammatory, antioxidative, antiviral, and antimicrobial activity. The exact mechanisms of action are not fully understood. Methods. We examined the effect of the extract and its main compound, berberine, on LPS-induced inflammatory activity in a murine macrophage cell line. RAW 264.7 cells were stimulated with LPS and incubated with either Rhizoma coptidis extract or berberine. Activation of AP-1 and NF B was analyzed in nuclear extracts, secretion of MCP-1/CCL2 was measured in supernatants. Results. Incubation with Rhizoma coptidis and berberine strongly inhibited LPS-induced monocyte chemoattractant protein (MCP)-1 production in RAW cells. Activation of the transcription factors AP-1 and NF B was inhibited by Rhizoma coptidis in a dose- and time-dependent fashion. Conclusions. Rhizoma coptidis extract inhibits LPS-induced MCP-1/CCL2 production in vitro via an AP-1 and NF B-dependent pathway. Anti-inflammatory action of the extract is mediated mainly by its alkaloid compound berberine. |
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| DOI: | doi:10.1155/2010/194896 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1155/2010/194896 |
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| | Volltext: https://www.hindawi.com/journals/mi/2010/194896/ |
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| | DOI: https://doi.org/10.1155/2010/194896 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1845302869 |
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| Verknüpfungen: | → Zeitschrift |
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Rhizoma coptidis inhibits LPS-induced MCP-1/CCL2 production in murine macrophages via an AP-1 and NFk B-dependent pathway / Remppis, Bjoern-Andrew [VerfasserIn]; 21 Jun 2010 (Online-Ressource)
