Exploring (peri-) lesional and structural connectivity tissue damage through T1/T2-weighted ratio in iron rim multiple sclerosis lesions

• Verfasst von: Wittayer, Matthias Sebastian [VerfasserIn]
• Verfasst von: Weber, Claudia Ellen [VerfasserIn]
• Verfasst von: Krämer, Julia [VerfasserIn]
• Verfasst von: Platten, Michael [VerfasserIn]
• Verfasst von: Schirmer, Lucas [VerfasserIn]
• Verfasst von: Gass, Achim [VerfasserIn]
• Verfasst von: Eisele, Philipp [VerfasserIn]
• Titel: Exploring (peri-) lesional and structural connectivity tissue damage through T1/T2-weighted ratio in iron rim multiple sclerosis lesions
• Verf.angabe: Matthias Wittayer, Claudia E. Weber, Julia Krämer, Michael Platten, Lucas Schirmer, Achim Gass, Philipp Eisele
• E-Jahr: 2023
• Jahr: January 2023
• Umfang: p12-18$t7
• Fussnoten: Gesehen am 15.05.2023
• Titel Quelle: Enthalten in: Magnetic resonance imaging
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1982
• Jahr Quelle: 2023
• Band/Heft Quelle: 95(2023) vom: Jan.
• ISSN Quelle: 1873-5894
• DOI: doi:10.1016/j.mri.2022.10.009
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Chronic active lesions
• Sach-SW: iron rim lesions
• Sach-SW: Magnetic resonance imaging
• Sach-SW: Multiple sclerosis
• Sach-SW: T1/T2-weighted ratio
• K10plus-PPN: 1845373170

Abstract

Objective - In multiple sclerosis (MS), iron rim lesions (IRLs) on magnetic resonance imaging (MRI) are associated with pronounced intralesional tissue damage. The aim of this study was to investigate (peri-)lesional and structural connectivity tissue damage in IRLs compared to non-IRLs. - Material and methods - MRI was acquired on a 3 T system. Tissue integrity was assessed using the T1/T2-weighted (T1/T2w) ratio. Furthermore, we assessed the impact on structural network connectivity accounting for differences in lesion volumes and T1/T2w values. - Results - Seventy-six patients (38 with at least one IRL and 38 age- and sex-matched patients without IRLs) were included. In the IRL-group, T1/T2w ratios of IRLs were significantly lower compared to non-IRLs (p < 0.05). When comparing the T1/T2w ratios in non-IRLs between the IRL-group and non-IRL group, there was no significant difference (p = 0.887). We observed a centrifugal decrease in microstructural damage from lesions to the perilesional white matter. In the IRL-group, T1/T2w ratios in the perilesional white matter 3-8 mm distant to the lesion were significantly lower in IRLs compared to non-IRLs. We found no significant differences in the amount of network disruption between both lesion types (p = 0.122). - Conclusion - T1/T2w represents an interesting candidate to capture a pronounced intra- and perilesional tissue damage of IRLs. However, our preliminary results suggest that a pronounced tissue damage might not result in a higher disruption to structural connectivity networks in IRLs.