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Verfasst von:Kalinichenko, Liubov [VerfasserIn]   i
 Smaga, Irena [VerfasserIn]   i
 Filip, Malgorzata [VerfasserIn]   i
 Lenz, Bernd [VerfasserIn]   i
 Kornhuber, Johannes [VerfasserIn]   i
 Müller, Christian P. [VerfasserIn]   i
Titel:Sex-specific effects of different types of prenatal stress on foetal testosterone levels and NMDA expression in mice
Verf.angabe:Liubov S. Kalinichenko, Irena Smaga, Malgorzata Filip, Bernd Lenz, Johannes Kornhuber, Christian P. Müller
E-Jahr:2023
Jahr:15 February 2023
Umfang:6 S.
Fussnoten:Online verfügbar 23 November 2022, Artikelversion 1 December 2022 ; Gesehen am 15.05.2023
Titel Quelle:Enthalten in: Behavioural brain research
Ort Quelle:Amsterdam : Elsevier, 1980
Jahr Quelle:2023
Band/Heft Quelle:439(2023) vom: Feb., Artikel-ID 114225, Seite 1-6
ISSN Quelle:1872-7549
Abstract:Prenatal stress is a critical life event often resulting in mental illnesses in the offspring. The critical developmental processes, which might trigger a cascade of molecular events resulting in mental disorders in adulthood, are still to be elucidated. Here we proposed that sex hormones, particularly testosterone, might determine the “developmental programming” of long-term consequences of prenatal stress in foetuses of both sexes. We observed that severe prenatal stress in the model of repeated corticosterone injections enhanced brain levels of corticosterone and testosterone in male foetuses. The expression of GluN1 and GluN2A, but not GluN2B NMDA receptor subunits were significantly reduced in the brain of stressed male foetuses. However, female foetuses were protected against stress effects on the brain corticosterone and testosterone levels. More moderate types of stress, such as repeated restraint stress and chronic unpredictable stress, did not induce an increase in brain corticosterone in dams and testosterone concentrations in foetuses of both sexes. Moreover, chronic unpredictable stress reduced brain testosterone concentration in male foetuses. Altogether, changes in brain testosterone level might be one of the crucial mechanisms determining the development of long-term consequences of severe prenatal stress in male, but not in female foetuses. Targeting this mechanism might allow to develop principally new prediction and therapeutic approaches for prenatal stress-associated psychiatric disorders.
DOI:doi:10.1016/j.bbr.2022.114225
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1016/j.bbr.2022.114225
 Volltext: https://www.sciencedirect.com/science/article/pii/S0166432822004946
 DOI: https://doi.org/10.1016/j.bbr.2022.114225
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Developmental programming
 Gender differences
 NMDA
 Prenatal stress
 Testosterone
K10plus-PPN:1845389549
Verknüpfungen:→ Zeitschrift

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