MR imaging-guided intravenous thrombolysis in posterior cerebral artery stroke

• Verfasst von: Förster, Alex [VerfasserIn]
• Verfasst von: Gass, Achim [VerfasserIn]
• Verfasst von: Kern, Rolf [VerfasserIn]
• Verfasst von: Wolf, Marc [VerfasserIn]
• Verfasst von: Hennerici, Michael G. [VerfasserIn]
• Verfasst von: Szabo, Kristina [VerfasserIn]
• Titel: MR imaging-guided intravenous thrombolysis in posterior cerebral artery stroke
• Verf.angabe: A. Förster, A. Gass, R. Kern, M.E. Wolf, M.G. Hennerici, K. Szabo
• E-Jahr: 2011
• Jahr: February 11, 2011
• Umfang: 3 S.
• Fussnoten: Gesehen am 15.05.2023
• Titel Quelle: Enthalten in: American journal of neuroradiology
• Ort Quelle: Oak Brook, Ill. : Soc., 1980
• Jahr Quelle: 2011
• Band/Heft Quelle: 32(2011), 2 vom: Feb., Seite 419-421
• ISSN Quelle: 1936-959X
• DOI: doi:10.3174/ajnr.A2300
• Datenträger: Online-Ressource
• Sprache: eng
• Bibliogr. Hinweis: Erscheint auch als : Druck-Ausgabe: Förster, Alex, 1978 - : MR imaging-guided intravenous thrombolysis in posterior cerebral artery stroke. - 2011
• K10plus-PPN: 1845392094

Abstract

SUMMARY: PCA stroke was under-represented in or excluded from the clinical trials examining thrombolysis based on the PWI-DWI mismatch concept. We present 6 patients with PCA stroke treated with thrombolysis in an extended time window by using MR imaging criteria. Symptoms included aphasia, sensorimotor hemiparesis, hemineglect, and homonymous hemianopia. Initial MR imaging demonstrated circumscribed ischemic lesions in the thalamus or hippocampus; MR angiography showed PCA occlusion with corresponding hypoperfusion. Follow-up MR imaging showed partial/complete recanalization in 4 patients with minor infarction growth, while in 1 patient, PCA occlusion persisted, resulting in a large PCA infarction. Three patients improved within 2 hours; at discharge, homonymous hemianopia had resolved in 3 patients. At 3-month follow-up, 4 patients had an mRS score of 0 or 1. These results support the approach to treat patients with PCA stroke with thrombolysis based on the mismatch concept. Because rehabilitation options for hemianopia are limited, thrombolysis may enhance the chance of a favorable outcome.