Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Riedmüller, Karen [VerfasserIn]   i
 Metz, Stephan [VerfasserIn]   i
 Bonaterra, Gabriel A. [VerfasserIn]   i
 Kelber, Olaf [VerfasserIn]   i
 Weiser, Dieter [VerfasserIn]   i
 Metz, Jürgen [VerfasserIn]   i
 Kinscherf, Ralf [VerfasserIn]   i
Titel:Cholesterol diet and effect of long-term withdrawal on plaque development and composition in the thoracic aorta of New Zealand White rabbits
Verf.angabe:Karen Riedmüller, Stephan Metz, Gabriel A. Bonaterra, Olaf Kelber, Dieter Weiser, Jürgen Metz, Ralf Kinscherf
E-Jahr:2010
Jahr:22 January 2010
Umfang:7 S.
Fussnoten:Gesehen am 15.05.2023
Titel Quelle:Enthalten in: Atherosclerosis
Ort Quelle:Amsterdam [u.a.] : Elsevier Science, 1970
Jahr Quelle:2010
Band/Heft Quelle:210(2010), 2 vom: Jan., Seite 407-413
ISSN Quelle:1879-1484
Abstract:Aims - Experimental study on plaque progression, regression and composition in atherosclerotic thoracic aorta of hypercholesterolemic rabbits after long-term withdrawal of cholesterol-enriched diet (CED). - Methods - Rabbits were fed 2% cholesterol for 6 weeks followed by withdrawal periods for 15, 23, 34, 68, or 78 weeks. Cholesterol, triglyceride, and phospholipids levels in blood and cholesterol concentrations in aorta were quantified. Plaque size and cellularity, phenotype of macrophages and smooth muscle cells were (immuno)histomorphometrically analyzed in segments of the thoracic aorta. - Results - After 6 weeks of CED, blood cholesterol levels were about 80-fold higher, whereas atherosclerosis and cholesterol content in the thoracic aorta were only minimally increased. However, the latter significantly increased within 15 weeks after cholesterol withdrawal, while serum cholesterol level was still 10-fold increased. Thereafter plaque area and cholesterol content remained almost unchanged until the end of the study despite a long-term normalization of serum cholesterol level after withdrawal of CED. Directly after 6 weeks of CED the densities of macrophages and apoptotic cells within plaques were highest, decreasing after cholesterol withdrawal, whereas, vice versa the density of smooth muscle cells (SMCs) significantly increased. - Conclusion - We suggest that atherosclerotic plaques respond to long-term withdrawal of CED by decrease in number and phenotype of macrophages and increase of SMCs without regression of the lesion size. The cellular changes are suggested to considerably contribute to higher plaque stability.
DOI:doi:10.1016/j.atherosclerosis.2010.01.009
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1016/j.atherosclerosis.2010.01.009
 Volltext: https://www.sciencedirect.com/science/article/pii/S0021915010000559
 DOI: https://doi.org/10.1016/j.atherosclerosis.2010.01.009
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Apoptosis
 Atherosclerosis
 Cholesterol
 Macrophages
 Plaque regression
 Plaque stability
 Smooth muscle cells
K10plus-PPN:1845408500
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/69075897   QR-Code
zum Seitenanfang