Neurotrophins

• Verfasst von: Weihrauch, Tobias [VerfasserIn]
• Verfasst von: Limberg, Maren [VerfasserIn]
• Verfasst von: Gray, Natalie [VerfasserIn]
• Verfasst von: Schmelz, Martin [VerfasserIn]
• Verfasst von: Raap, Ulrike [VerfasserIn]
• Titel: Neurotrophins
• Titelzusatz: neuroimmune interactions in human atopic diseases
• Verf.angabe: Tobias Weihrauch, Maren M. Limberg, Natalie Gray, Martin Schmelz and Ulrike Raap
• E-Jahr: 2023
• Jahr: 24 March 2023
• Umfang: 14 S.
• Titel Quelle: Enthalten in: International journal of molecular sciences
• Ort Quelle: Basel : Molecular Diversity Preservation International, 2000
• Jahr Quelle: 2023
• Band/Heft Quelle: 24(2023), 7, Artikel-ID 6105, Seite 1-14
• ISSN Quelle: 1422-0067
• ISSN Quelle: 1661-6596
• DOI: doi:10.3390/ijms24076105
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1841983306

Abstract

Allergic diseases are accompanied by a variety of symptoms such as pruritus, coughing, sneezing, and watery eyes, which can result in severe physiological and even psychological impairments. The exact mechanisms of these conditions are not yet completely understood. However, recent studies demonstrated a high relevance of neurotrophins in allergic inflammation, as they induce cytokine release, mediate interaction between immune cells and neurons, and exhibit different expression levels in health and disease. In this review, we aim to give an overview of the current state of knowledge concerning the role of neurotrophins in atopic disorders such as atopic dermatitis, allergic asthma, and allergic rhinitis.