Persistence of Candida species in the respiratory tract of cystic fibrosis patients

• Verfasst von: Muthig, Michaela [VerfasserIn]
• Verfasst von: Hebestreit, Alexandra [VerfasserIn]
• Verfasst von: Ziegler, Uwe [VerfasserIn]
• Verfasst von: Seidler, Marc [VerfasserIn]
• Verfasst von: Müller, Frank-Michael [VerfasserIn]
• Titel: Persistence of Candida species in the respiratory tract of cystic fibrosis patients
• Verf.angabe: Michaela Muthig, Alexandra Hebestreit, Uwe Ziegler, Marc Seidler & Frank-Michael C. Müller
• E-Jahr: 2010
• Jahr: 01 February 2010
• Umfang: 8 S.
• Fussnoten: Gesehen am 17.05.2023
• Titel Quelle: Enthalten in: Medical mycology
• Ort Quelle: Oxford : Oxford Univ. Press, 1998
• Jahr Quelle: 2010
• Band/Heft Quelle: 48(2010), 1 vom: Feb., Seite 56-63
• ISSN Quelle: 1460-2709
• DOI: doi:10.3109/13693780802716532
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1845626133

Abstract

It is still controversial as to whether Candida spp. are transient or persistent colonizers of the respiratory tract of cystic fibrosis (CF) patients. We conducted a prospective study of 56 CF patients over a 30 month period to assess the distribution and persistence of different Candida spp. In vitro antifungal susceptibility testing was performed and the C. albicans isolates were typed with CARE-2 hybridization and other Candida spp. by RAPD-PCR for persistence and transmission. We found that the mean persistence of the most frequent Candida spp. was ≥ 9 months. In patients from whom more than 10 isolates were recovered, we noted that at least 30% were genetically related and transmission of C. albicans in siblings was observed. The majority of all isolates were susceptible to all antifungals tested. We concluded that there was long-term persistence of Candida in the respiratory tract of CF patients and that transmission between siblings may be one possible means of acquisition. Whether long-term colonization with Candida strains can contribute to the chronic infection and inflammation in the CF lung requires further investigation.