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| Verfasst von: | Stich, Maximilian [VerfasserIn]  |
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| | Benning, Louise [VerfasserIn] |
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| | Speer, Claudius [VerfasserIn] |
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| | Garbade, Sven [VerfasserIn] |
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| | Bartenschlager, Marie [VerfasserIn] |
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| | Kim, Heeyoung [VerfasserIn] |
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| | Jeltsch, Kathrin [VerfasserIn] |
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| | Tabatabai, Julia [VerfasserIn] |
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| | Niesert, Moritz [VerfasserIn] |
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| | Janda, Aleš [VerfasserIn] |
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| | Renk, Hanna [VerfasserIn] |
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| | Elling, Roland [VerfasserIn] |
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| | Hoffmann, Georg F. [VerfasserIn] |
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| | Kräusslich, Hans-Georg [VerfasserIn] |
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| | Müller, Barbara [VerfasserIn] |
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| | Bartenschlager, Ralf [VerfasserIn] |
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| | Tönshoff, Burkhard [VerfasserIn] |
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| Titel: | Live-virus neutralization of the omicron variant in children and adults 14 months after SARS-CoV-2 wild-type infection |
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| Verf.angabe: | Maximilian Stich, Louise Benning, Claudius Speer, Sven F. Garbade, Marie Bartenschlager, Heeyoung Kim, Kathrin Jeltsch, Julia Tabatabai, Moritz Niesert, Aleš Janda, Hanna Renk, Roland Elling, Georg Friedrich Hoffmann, Hans-Georg Kräusslich, Barbara Müller, Ralf Bartenschlager, Burkhard Tönshoff |
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| E-Jahr: | 2023 |
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| Jahr: | 16 February 2023 |
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| Umfang: | 11 S. |
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| Fussnoten: | Gesehen am 22.05.2023 |
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| Titel Quelle: | Enthalten in: Journal of medical virology |
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| Ort Quelle: | Bognor Regis [u.a.] : Wiley, 1977 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 95(2023), 3 vom: Feb., Artikel-ID e28582, Seite 1-11 |
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| ISSN Quelle: | 1096-9071 |
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| Abstract: | Data on cross-neutralization of the SARS-CoV-2 omicron variant more than 1 year after SARS-CoV-2 infection are urgently needed, especially in children, to predict the likelihood of reinfection and to guide vaccination strategies. In a prospective observational cohort study, we evaluated live-virus neutralization of the SARS-CoV-2 omicron (BA.1) variant in children compared with adults 14 months after mild or asymptomatic wild-type SARS-CoV-2 infection. We also evaluated immunity to reinfection conferred by previous infection plus COVID-19 mRNA vaccination. We studied 36 adults and 34 children 14 months after acute SARS-CoV-2 infection. While 94% of unvaccinated adults (16/17) and children (32/34) neutralized the delta (B.1.617.2) variant, only 1/17 (5.9%) unvaccinated adults, 0/16 (0%) adolescents and 5/18 (27.8%) children <12 years of age had neutralizing activity against omicron (BA.1). In convalescent adults, one or two doses of mRNA vaccine increased delta and omicron neutralization 32-fold, similar to a third mRNA vaccination in uninfected adults. Neutralization of omicron was 8-fold lower than that of delta in both groups. In conclusion, our data indicate that humoral immunity induced by previous SARS-CoV-2 wild-type infection more than 1 year ago is insufficient to neutralize the current immune escape omicron variant. |
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| DOI: | doi:10.1002/jmv.28582 |
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| URL: | kostenfrei: Volltext: https://doi.org/10.1002/jmv.28582 |
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| | kostenfrei: Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/jmv.28582 |
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| | DOI: https://doi.org/10.1002/jmv.28582 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | children |
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| | COVID-19 |
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| | immune escape |
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| | live-virus neutralization |
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| | omicron variant |
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| | SARS-CoV-2 |
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| | vaccination |
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| K10plus-PPN: | 1845905369 |
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| Verknüpfungen: | → Zeitschrift |
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| Lokale URL UB: |  Zum Volltext |
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Live-virus neutralization of the omicron variant in children and adults 14 months after SARS-CoV-2 wild-type infection / Stich, Maximilian [VerfasserIn]; 16 February 2023 (Online-Ressource)
