Prevalence and determinants of reticular pseudodrusen in the Russian Ural Eye and Medical Study

• Verfasst von: Bikbov, Mukharram [VerfasserIn]
• Verfasst von: Kazakbaeva, Gyulli M. [VerfasserIn]
• Verfasst von: Rakhimova, Ellina M. [VerfasserIn]
• Verfasst von: Rusakova, Iuliia A. [VerfasserIn]
• Verfasst von: Gilmanshin, Timur R. [VerfasserIn]
• Verfasst von: Zainullin, Rinat M. [VerfasserIn]
• Verfasst von: Panda-Jonas, Songhomitra [VerfasserIn]
• Verfasst von: Fakhretdinova, Albina A. [VerfasserIn]
• Verfasst von: Tuliakova, Azaliia M. [VerfasserIn]
• Verfasst von: Safiullina, Kamilia R. [VerfasserIn]
• Verfasst von: Bolshakova, Natalia I. [VerfasserIn]
• Verfasst von: Gizzatov, Ainur V. [VerfasserIn]
• Verfasst von: Ponomarev, Ildar P. [VerfasserIn]
• Verfasst von: Jonas, Jost B. [VerfasserIn]
• Titel: Prevalence and determinants of reticular pseudodrusen in the Russian Ural Eye and Medical Study
• Verf.angabe: Mukharram M. Bikbov, Gyulli M. Kazakbaeva, Ellina M. Rakhimova, Iuliia A. Rusakova, Timur R. Gilmanshin, Rinat M. Zainullin, Songhomitra Panda-Jonas, Albina A. Fakhretdinova, Azaliia M. Tuliakova, Kamilia R. Safiullina, Natalia I. Bolshakova, Ainur V. Gizzatov, Ildar P. Ponomarev and Jost B. Jonas
• E-Jahr: 2022
• Jahr: December 2022
• Umfang: 7 S.
• Fussnoten: Gesehen am 22.05.2023
• Titel Quelle: Enthalten in: Acta ophthalmologica
• Ort Quelle: Oxford : Blackwell, 2008
• Jahr Quelle: 2022
• Band/Heft Quelle: 100(2022), 8, Seite e1701-e1707
• ISSN Quelle: 1755-3768
• DOI: doi:10.1111/aos.15145
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: age-related macular degeneration
• Sach-SW: epidemiology
• Sach-SW: macula
• Sach-SW: myopia
• Sach-SW: population-based study
• Sach-SW: reticular pseudodrusen
• Sach-SW: retina
• Sach-SW: subretinal drusenoid deposits
• Sach-SW: Ural Eye and Medical Study
• K10plus-PPN: 1845931874
• K10plus-PPN:
  Universitätsbibliothek
• Lokale URL UB: Zum Volltext

Abstract

Purpose To assess the prevalence of reticular pseudodrusen (RPD) and their determinants. Methods The Population-based Ural Eye and Medical Study conducted in Bashkortostan/Russia included 5899 participants aged 40+ years. Presence of RPDs was assessed on conventional colour fundus photographs, red-free fundus images and optical coherence tomographic images. Results The study included 4914 (83.3%) individuals (mean age: 58.5 ± 10.5 years; range: 40-94 years). Using two age limits (>55 years and 40+ years) for the definitions of RPD and AMD (age-related macular degeneration), RPD prevalence was 186/4914 (3.8%; 95% confidence interval (CI): 3.3, 4.3) and 246/4914 (5.0%, 95% CI: 4.4, 5.6), respectively, and the prevalence of any AMD without RPD was 182/4914 (3.7%: 95% CI: 3.2, 4.2) and 224/4914 (4.6%; 95% CI: 4.0, 5.1) respectively. Within the subgroup of early AMD, intermediate AMD and late AMD, RPD prevalence (age limit: 40+ years) was 55.1% (95% CI: 49.5, 60.8), 42.9% (95% CI: 33.8, 51.9) and 33.3% (95% CI: 16.4, 50.3) respectively. In multivariable analysis, higher RPD prevalence (age limit 40+ years) was associated with higher age (odds ratio (OR): 1.08; 95% CI: 1.07, 1.10; p < 0.001), rural region of habitation (OR: 3.81; 95% CI: 2.76, 5.24; p < 0.001) and lower percentage of lymphocytes on leukocyte counts (OR: 0.95; 95% CI: 0.93, 0.97; p < 0.001). Higher prevalence of any AMD without RPD was associated with urban region (OR: 1.58; 95% CI: 1.18, 2.11; p = 0.002), lower diabetes prevalence (OR: 0.55; 95% CI: 0.33, 0.90; p = 0.02) and shorter axial length (OR: 0.85; 95% CI: 0.74, 0.98; p = 0.03), after adjusting for age. Conclusions Reticular pseudodrusen (mean prevalence: 3.8% (age limit >55 years); 5.0% (age limit 40+ years)) differs from AMD without RPD in its association with urban region (AMD without RPD: rural region), lower lymphocyte percentage (AMD without RPD: no association) and a lack of associations with axial length (AMD without RPD: shorter axial length) and with diabetes prevalence (AMD without RPD: lower diabetes prevalence).