Dendritic cells control T cell tonic signaling required for responsiveness to foreign antigen

• Verfasst von: Hochweller, Kristin [VerfasserIn]
• Verfasst von: Wabnitz, Guido H. [VerfasserIn]
• Verfasst von: Samstag, Yvonne [VerfasserIn]
• Verfasst von: Suffner, Janine [VerfasserIn]
• Verfasst von: Hämmerling, Günter J. [VerfasserIn]
• Verfasst von: Garbi, Natalio [VerfasserIn]
• Titel: Dendritic cells control T cell tonic signaling required for responsiveness to foreign antigen
• Verf.angabe: Kristin Hochweller, Guido H. Wabnitz, Yvonne Samstag, Janine Suffner, Günter J. Hämmerling, and Natalio Garbi
• E-Jahr: 2010
• Jahr: [March 30, 2010]
• Umfang: 6 S.
• Illustrationen: Illustrationen
• Fussnoten: Gesehen am 24.05.2023
• Titel Quelle: Enthalten in: National Academy of Sciences (Washington, DC)Proceedings of the National Academy of Sciences of the United States of America
• Ort Quelle: Washington, DC : National Acad. of Sciences, 1915
• Jahr Quelle: 2010
• Band/Heft Quelle: 107(2010), 13 vom: März, Seite 5931-5936
• ISSN Quelle: 1091-6490
• DOI: doi:10.1073/pnas.0911877107
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1846053005

Abstract

Dendritic cells (DCs) are key components of the adaptive immune system contributing to initiation and regulation of T cell responses. T cells continuously scan DCs in lymphoid organs for the presence of foreign antigen. However, little is known about the functional consequences of these frequent T cell-DC interactions without cognate antigen. Here we demonstrate that these contacts in the absence of foreign antigen serve an important function, namely, induction of a basal activation level in T cells required for responsiveness to subsequent encounters with foreign antigens. This basal activation is provided by self-recognition of MHC molecules on DCs. Following DC depletion in mice, T cells became impaired in TCR signaling and immune synapse formation, and consequently were hyporesponsive to antigen. This process was reversible, as T cells quickly recovered when the number of DCs returned to a normal level. The extent of T cell reactivity correlated with the degree of DC depletion in lymphoid organs, suggesting that a full DC compartment guarantees optimal T cell responsiveness. These findings indicate that DCs are specialized cells that not only present foreign antigen, but also promote a “tonic” state in T cells for antigen responsiveness.