Comparing gene expression in deep infiltrating endometriosis with adenomyosis uteri

• Verfasst von: Marshall, Anne [VerfasserIn]
• Verfasst von: Kommoss, Felix [VerfasserIn]
• Verfasst von: Ortmann, H. [VerfasserIn]
• Verfasst von: Kirchner, Martina [VerfasserIn]
• Verfasst von: Jauckus, J. [VerfasserIn]
• Verfasst von: Sinn, Peter [VerfasserIn]
• Verfasst von: Strowitzki, Thomas [VerfasserIn]
• Verfasst von: Germeyer, Ariane [VerfasserIn]
• Titel: Comparing gene expression in deep infiltrating endometriosis with adenomyosis uteri
• Titelzusatz: evidence for dysregulation of oncogene pathways
• Verf.angabe: A. Marshall, K.F. Kommoss, H. Ortmann, M. Kirchner, J. Jauckus, P. Sinn, T. Strowitzki and A. Germeyer
• E-Jahr: 2023
• Jahr: 01 April 2023
• Umfang: 11 S.
• Fussnoten: Gesehen am 24.05.2023
• Titel Quelle: Enthalten in: Reproductive biology and endocrinology
• Ort Quelle: London : Biomed Central, 2003
• Jahr Quelle: 2023
• Band/Heft Quelle: 21(2023) vom: Apr., Artikel-ID 33, Seite 1-11
• ISSN Quelle: 1477-7827
• DOI: doi:10.1186/s12958-023-01083-9
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Adenomyosis
• Sach-SW: Deep infiltrating endometriosis
• Sach-SW: Gene expression analysis
• Sach-SW: PI3K pathway
• Sach-SW: RAS pathway
• K10plus-PPN: 1846078733
• K10plus-PPN:
  Universitätsbibliothek
• Lokale URL UB: Zum Volltext

Abstract

The pathogenesis of deep infiltrating endometriosis (DIE) is poorly understood. It is considered a benign disease but has histologic features of malignancy, such as local invasion or gene mutations. Moreover, it is not clear whether its invasive potential is comparable to that of adenomyosis uteri (FA), or whether it has a different biological background. Therefore, the aim of this study was to molecularly characterize the gene expression signatures of both diseases in order to gain insight into the common or different underlying pathomechanisms and to provide clues to pathomechanisms of tumor development based on these diseases.