Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Englisch, Susanne Angelika [VerfasserIn]   i
 Enning, Frank [VerfasserIn]   i
 Großhans, Martin [VerfasserIn]   i
 Marquardt, Lars [VerfasserIn]   i
 Waltereit, Robert [VerfasserIn]   i
 Zink, Mathias [VerfasserIn]   i
Titel:Quetiapine combined with amisulpride in schizophrenic patients with insufficient responses to quetiapine monotherapy
Verf.angabe:Susanne Englisch, Frank Enning, Martin Grosshans, Lars Marquardt, Robert Waltereit, and Mathias Zink
Jahr:2010
Umfang:3 S.
Fussnoten:Gesehen am 25.05.2023
Titel Quelle:Enthalten in: Clinical neuropharmacology
Ort Quelle:Philadelphia, Pa. : Lippincott Williams & Wilkins, 1976
Jahr Quelle:2010
Band/Heft Quelle:33(2010), 5 vom: Sept./Okt., Seite 227-229
ISSN Quelle:1537-162X
Abstract:Objectives: Treatment resistance often leads to combinations of second-generation antipsychotics. Well-designed trials evaluated add-on strategies involving clozapine, but also olanzapine and quetiapine (QTP) have pharmacodynamic properties that render supplementation with high-affinity antidopaminergic second-generation antipsychotics, for example, amisulpride (AMS), reasonable. - Methods: We report on 6 cases with partial response of psychotic positive symptoms to QTP despite sufficient dosage (mean, 783 mg/d) and serum levels (mean, 405 μg/L). Concomitant drug abuse and interfering pharmacological changes were excluded. - Results: The add-on of AMS in a mean dose of 466.7 mg/d (serum level, 132.1 μg/L) over a period of 8.3 weeks facilitated significant improvements of treatment-resistant psychotic symptoms. The Positive and Negative Syndrome Scale scores decreased from 94 to 54, whereas the Scale for the Assessment of Negative Symptoms and the Calgary Depression Scale for Schizophrenia significantly improved. Despite an increase in the mean body weight from 77.2 to 82.9 kg and an increase in prolactin levels from 43 to 163 μg/L, the observed general tolerance was good. - Conclusions: The combination of AMS with QTP might be a successful strategy in individuals only partially responsive to quetiapine, but risks and benefits should be further evaluated in controlled clinical trials.
DOI:doi:10.1097/WNF.0b013e3181f0f013
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1097/WNF.0b013e3181f0f013
 Volltext: https://journals.lww.com/clinicalneuropharm/Fulltext/2010/09000/Quetiapine_Combined_With_Amisulpride_in.3.aspx
 DOI: https://doi.org/10.1097/WNF.0b013e3181f0f013
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1846190487
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/69079357   QR-Code
zum Seitenanfang