Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Rochet, Nathalie [VerfasserIn]   i
 Sterzing, Florian [VerfasserIn]   i
 Jensen, Alexandra [VerfasserIn]   i
 Dinkel, Julien [VerfasserIn]   i
 Herfarth, Klaus [VerfasserIn]   i
 Schubert, Kai [VerfasserIn]   i
 Eichbaum, Michael H. R. [VerfasserIn]   i
 Schneeweiss, Andreas [VerfasserIn]   i
 Sohn, Christof [VerfasserIn]   i
 Debus, Jürgen [VerfasserIn]   i
 Harms, Wolfgang [VerfasserIn]   i
Titel:Intensity-modulated whole abdominal radiotherapy after surgery and carboplatin/taxane chemotherapy for advanced ovarian cancer
Titelzusatz:phase I study
Verf.angabe:Nathalie Rochet, M.D., Florian Sterzing, M.D., Alexandra D. Jensen, M.D., Julien Dinkel, M.D., Klaus K. Herfarth, M.D., Kai Schubert, Ph.D., Michael H. Eichbaum, M.D., Andreas Schneeweiss, M.D., Christof Sohn, M.D., Juergen Debus, M.D., Ph.D., and Wolfgang Harms, M.D.
Jahr:2010
Umfang:8 S.
Fussnoten:Erstmals am 21. Juli 2009 online veröffentlicht ; Gesehen am 25.05.2023
Titel Quelle:Enthalten in: International journal of radiation oncology, biology, physics
Ort Quelle:Amsterdam [u.a.] : Elsevier Science, 1975
Jahr Quelle:2010
Band/Heft Quelle:76(2010), 5 vom: Apr., Seite 1382-1389
ISSN Quelle:1879-355X
Abstract:Purpose - To assess the feasibility and toxicity of consolidative intensity-modulated whole abdominal radiotherapy (WAR) after surgery and chemotherapy in high-risk patients with advanced ovarian cancer. - Methods and Materials - Ten patients with optimally debulked ovarian cancer International Federation of Gynecology and Obstetrics Stage IIIc were treated in a Phase I study with intensity-modulated WAR up to a total dose of 30 Gy in 1.5-Gy fractions as consolidation therapy after adjuvant carboplatin/taxane chemotherapy. Treatment was delivered using intensity-modulated radiotherapy in a step-and-shoot technique (n = 3) or a helical tomotherapy technique (n = 7). The planning target volume included the entire peritoneal cavity and the pelvic and para-aortal node regions. Organs at risk were kidneys, liver, heart, vertebral bodies, and pelvic bones. - Results - Intensity-modulated WAR resulted in an excellent coverage of the planning target volume and an effective sparing of the organs at risk. The treatment was well tolerated, and no severe Grade 4 acute side effects occurred. Common Toxicity Criteria Grade III toxicities were as follows: diarrhea (n = 1), thrombocytopenia (n = 1), and leukopenia (n = 3). Radiotherapy could be completed by all the patients without any toxicity-related interruption. Median follow-up was 23 months, and 4 patients had tumor recurrence (intraperitoneal progression, n = 3; hepatic metastasis, n = 1). Small bowel obstruction caused by adhesions occurred in 3 patients. - Conclusions - The results of this Phase I study showed for the first time, to our knowledge, the clinical feasibility of intensity-modulated whole abdominal radiotherapy, which could offer a new therapeutic option for consolidation treatment of advanced ovarian carcinoma after adjuvant chemotherapy in selected subgroups of patients. We initiated a Phase II study to further evaluate the toxicity of this intensive multimodal treatment.
DOI:doi:10.1016/j.ijrobp.2009.03.061
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1016/j.ijrobp.2009.03.061
 Volltext: https://www.sciencedirect.com/science/article/pii/S0360301609005744
 DOI: https://doi.org/10.1016/j.ijrobp.2009.03.061
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Consolidation treatment
 Helical tomotherapy
 Ovarian cancer
 Step-and-shoot intensity-modulated radiotherapy
 Whole abdominal radiotherapy
K10plus-PPN:1846204178
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/69079470   QR-Code
zum Seitenanfang