Stress triggers anhedonia in rats bred for learned helplessness

• Verfasst von: Enkel, Thomas [VerfasserIn]
• Verfasst von: Spanagel, Rainer [VerfasserIn]
• Verfasst von: Vollmayr, Barbara [VerfasserIn]
• Verfasst von: Schneider, Miriam [VerfasserIn]
• Titel: Stress triggers anhedonia in rats bred for learned helplessness
• Verf.angabe: Thomas Enkel, Rainer Spanagel, Barbara Vollmayr, Miriam Schneider
• E-Jahr: 2010
• Jahr: 1 February 2010
• Umfang: 4 S.
• Fussnoten: Gesehen am 25.05.2023
• Titel Quelle: Enthalten in: Behavioural brain research
• Ort Quelle: Amsterdam : Elsevier, 1980
• Jahr Quelle: 2010
• Band/Heft Quelle: 209(2010), 1 vom: Mai, Seite 183-186
• ISSN Quelle: 1872-7549
• DOI: doi:10.1016/j.bbr.2010.01.042
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Anhedonia
• Sach-SW: Depression
• Sach-SW: Learned helplessness
• Sach-SW: Pleasure-attenuated startle
• Sach-SW: Reward
• Sach-SW: Stress
• K10plus-PPN: 1846204801

Abstract

Congenitally helpless (cLH) rats, a well-accepted model for depression, show reduced consumption of sweet solutions only under single-housing conditions, indicating anhedonia under stress. We investigated if anhedonic-like behaviour, measured by a reduction of sweetened-condensed milk (SCM) intake and the pleasure-attenuated startle response (PAS), could be induced by an electric foot-shock stress challenge in group-housed rats. After foot-shock stress, reduced SCM intake was observed in cLH rats compared to non-helpless (cNLH) rats. Furthermore, cLH rats also showed a decreased PAS, indicating deficient reward perception. In summary, we demonstrate that a predisposition for learned helplessness interacts with stress to trigger anhedonic-like behaviour in cLH rats. These findings further add to the validity of congenitally learned helplessness as an animal model of depression, since gene-environment interactions are considered to play a role in the etiology of this disorder.