Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Grenda, Ryszard [VerfasserIn]   i
 Watson, A. [VerfasserIn]   i
 Trompeter, R. [VerfasserIn]   i
 Tönshoff, Burkhard [VerfasserIn]   i
 Jaray, J. [VerfasserIn]   i
 Fitzpatrick, M. [VerfasserIn]   i
 Murer, L. [VerfasserIn]   i
 Vondrak, K. [VerfasserIn]   i
 Maxwell, H. [VerfasserIn]   i
 Van Damme-Lombaerts, R. [VerfasserIn]   i
 Loirat, C. [VerfasserIn]   i
 Mor, E. [VerfasserIn]   i
 Cochat, P. [VerfasserIn]   i
 Milford, D. V. [VerfasserIn]   i
 Brown, M. [VerfasserIn]   i
 Webb, N. J. A. [VerfasserIn]   i
Titel:A randomized trial to assess the impact of early steroid withdrawal on growth in pediatric renal transplantation
Titelzusatz:the TWIST study
Verf.angabe:R. Grenda, A. Watson, R. Trompeter, B. Tönshoff, J. Jaray, M. Fitzpatrick, L. Murer, K. Vondrak, H. Maxwell, R. Van Damme-Lombaerts, C. Loirat, E. Mor, P. Cochat, D.V. Milford, M. Brown and N.J.A. Webb
E-Jahr:2010
Jahr:11 January 2010
Umfang:9 S.
Fussnoten:Gesehen am 25.05.2023
Titel Quelle:Enthalten in: American journal of transplantation
Ort Quelle:[Amsterdam] : Elsevier, 2001
Jahr Quelle:2010
Band/Heft Quelle:10(2010), 4, Seite 828-836
ISSN Quelle:1600-6143
Abstract:Minimizing steroid exposure in pediatric renal transplant recipients can improve linear growth and reduce metabolic disorders. This randomized multicenter study investigated the impact of early steroid withdrawal on mean change in height standard deviation score (SDS) and the safety and efficacy of two immunosuppressive regimens during the first 6 months after transplantation. Children received tacrolimus, MMF, two doses of daclizumab and steroids until day 4 (TAC/MMF/DAC, n = 98) or tacrolimus, MMF and standard-dose steroids (TAC/MMF/STR, n = 98). Mean change in height SDS was 0.16 ± 0.32 with TAC/MMF/DAC and 0.03 ± 0.32 with TAC/MMF/STR. The mean treatment group difference was 0.13 (p < 0.005 [95% CI 0.04-0.22]), 0.21 in prepubertal (p = 0.009 [95% CI 0.05-0.36]) and 0.05 in pubertal children (p = ns). Frequency of biopsy-proven acute rejection was 10.2%, TAC/MMF/DAC, and 7.1%, TAC/MMF/STR. Patient and graft survival and renal function were similar. Significantly greater reductions in total cholesterol and triglycerides but significantly higher incidences of infection and anemia were found with TAC/MMF/DAC (p < 0.05 all comparisons). Early steroid withdrawal significantly aided growth at 6 months more so in prepubertal than pubertal children. This was accompanied by significantly better lipid and glucose metabolism profiles without increases in graft rejection or loss.
DOI:doi:10.1111/j.1600-6143.2010.03047.x
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1111/j.1600-6143.2010.03047.x
 Volltext: https://www.sciencedirect.com/science/article/pii/S1600613522196528
 DOI: https://doi.org/10.1111/j.1600-6143.2010.03047.x
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Early steroid withdrawal
 linear growth
 pediatric kidney transplant
K10plus-PPN:1846224616
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/69079555   QR-Code
zum Seitenanfang