| |  Online-Ressource |
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| Verfasst von: | Ahmed, Azaz [VerfasserIn]  |
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| | Köhler, Sophia [VerfasserIn] |
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| | Klotz, Rosa [VerfasserIn] |
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| | Giese, Nathalia [VerfasserIn] |
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| | Hackert, Thilo [VerfasserIn] |
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| | Springfeld, Christoph [VerfasserIn] |
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| | Jäger, Dirk [VerfasserIn] |
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| | Halama, Niels [VerfasserIn] |
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| Titel: | Sex differences in the systemic and local immune response of pancreatic cancer patients |
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| Verf.angabe: | Azaz Ahmed, Sophia Köhler, Rosa Klotz, Nathalia Giese, Thilo Hackert, Christoph Springfeld, Dirk Jäger and Niels Halama |
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| E-Jahr: | 2023 |
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| Jahr: | 17 March 2023 |
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| Umfang: | 14 S. |
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| Fussnoten: | Gesehen am 24.05.2023 |
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| Titel Quelle: | Enthalten in: Cancers |
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| Ort Quelle: | Basel : MDPI, 2009 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 15(2023), 6, Artikel-ID 1815, Seite 1-14 |
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| ISSN Quelle: | 2072-6694 |
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| Abstract: | Background: Mounting evidence suggests that sex plays a critical role in various aspects of cancer such as immune responses. However, a male bias exists in human and non-human studies including immunotherapy trials. The role of sex on immune responses in pancreatic ductal adenocarcinoma (PDA) is unclear. Methods: Here, tumor tissues (tumor and stroma separately) and corresponding blood samples from patients with PDA (n = 52) were systematically analyzed by immunohistochemistry and multiplex cytokine measurements and compared by sex. Results: Females showed a stronger systemic immune response with higher levels of CXCL9, IL1B, IL6, IL10 and IL13. Additionally, more peripheral white blood cells were detected in females. In the microenvironment, males showed higher tumoral levels of CXCL12. No differences were detected in the stroma. Females showed a tendency towards an anti-tumoral immune cell profile. CXCL12 blockade indicated a differential microenvironmental effect by sex in an independent immunotherapy trial cohort of patients with PDA (one female, five males). The overall survival did not differ by sex in our cohort. Conclusion: Systemic and local immune responses differ between sexes in PDA. Accordingly, sex-dependent differences need to be considered in human studies and for specific immunological interventions before clinical translation. |
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| DOI: | doi:10.3390/cancers15061815 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.3390/cancers15061815 |
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| | kostenfrei: Volltext: https://www.mdpi.com/2072-6694/15/6/1815 |
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| | DOI: https://doi.org/10.3390/cancers15061815 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | CXCL12 |
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| | pancreatic cancer |
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| | pancreatic ductal adenocarcinoma |
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| | sex difference |
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| | tumor immunology |
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| K10plus-PPN: | 1846225213 |
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| Verknüpfungen: | → Zeitschrift |
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Sex differences in the systemic and local immune response of pancreatic cancer patients / Ahmed, Azaz [VerfasserIn]; 17 March 2023 (Online-Ressource)
