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Verfasst von:Pilz, Stefan [VerfasserIn]   i
 Trummer, Christian [VerfasserIn]   i
 Theiler-Schwetz, Verena [VerfasserIn]   i
 Grübler, Martin R. [VerfasserIn]   i
 Verheyen, Nicolas [VerfasserIn]   i
 Odler, Balazs [VerfasserIn]   i
 Karras, Spyridon N. [VerfasserIn]   i
 Zittermann, Armin [VerfasserIn]   i
 März, Winfried [VerfasserIn]   i
Titel:Critical appraisal of large vitamin D randomized controlled trials
Verf.angabe:Stefan Pilz, Christian Trummer, Verena Theiler-Schwetz, Martin R. Grübler, Nicolas D. Verheyen, Balazs Odler, Spyridon N. Karras, Armin Zittermann and Winfried März
E-Jahr:2022
Jahr:12 January 2022
Umfang:14 S.
Fussnoten:Gesehen am 30.05.2023
Titel Quelle:Enthalten in: Nutrients
Ort Quelle:Basel : MDPI, 2009
Jahr Quelle:2022
Band/Heft Quelle:14(2022), 2, Artikel-ID 303, Seite 1-14
ISSN Quelle:2072-6643
Abstract:As a consequence of epidemiological studies showing significant associations of vitamin D deficiency with a variety of adverse extra-skeletal clinical outcomes including cardiovascular diseases, cancer, and mortality, large vitamin D randomized controlled trials (RCTs) have been designed and conducted over the last few years. The vast majority of these trials did not restrict their study populations to individuals with vitamin D deficiency, and some even allowed moderate vitamin D supplementation in the placebo groups. In these RCTs, there were no significant effects on the primary outcomes, including cancer, cardiovascular events, and mortality, but explorative outcome analyses and meta-analyses revealed indications for potential benefits such as reductions in cancer mortality or acute respiratory infections. Importantly, data from RCTs with relatively high doses of vitamin D supplementation did, by the vast majority, not show significant safety issues, except for trials in critically or severely ill patients or in those using very high intermittent vitamin D doses. The recent large vitamin D RCTs did not challenge the beneficial effects of vitamin D regarding rickets and osteomalacia, that therefore continue to provide the scientific basis for nutritional vitamin D guidelines and recommendations. There remains a great need to evaluate the effects of vitamin D treatment in populations with vitamin D deficiency or certain characteristics suggesting a high sensitivity to treatment. Outcomes and limitations of recently published large vitamin D RCTs must inform the design of future vitamin D or nutrition trials that should use more personalized approaches.
DOI:doi:10.3390/nu14020303
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: https://doi.org/10.3390/nu14020303
 kostenfrei: Volltext: https://www.mdpi.com/2072-6643/14/2/303
 DOI: https://doi.org/10.3390/nu14020303
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:cholecalciferol
 clinical trial
 epidemiology
 infections
 mortality
 randomized controlled trial
 RCT
 supplementation
 vitamin D
K10plus-PPN:1846948193
Verknüpfungen:→ Zeitschrift

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