| Online-Ressource |
Verfasst von: | Pilz, Stefan [VerfasserIn]  |
| Trummer, Christian [VerfasserIn]  |
| Theiler-Schwetz, Verena [VerfasserIn]  |
| Grübler, Martin R. [VerfasserIn]  |
| Verheyen, Nicolas [VerfasserIn]  |
| Odler, Balazs [VerfasserIn]  |
| Karras, Spyridon N. [VerfasserIn]  |
| Zittermann, Armin [VerfasserIn]  |
| März, Winfried [VerfasserIn]  |
Titel: | Critical appraisal of large vitamin D randomized controlled trials |
Verf.angabe: | Stefan Pilz, Christian Trummer, Verena Theiler-Schwetz, Martin R. Grübler, Nicolas D. Verheyen, Balazs Odler, Spyridon N. Karras, Armin Zittermann and Winfried März |
E-Jahr: | 2022 |
Jahr: | 12 January 2022 |
Umfang: | 14 S. |
Fussnoten: | Gesehen am 30.05.2023 |
Titel Quelle: | Enthalten in: Nutrients |
Ort Quelle: | Basel : MDPI, 2009 |
Jahr Quelle: | 2022 |
Band/Heft Quelle: | 14(2022), 2, Artikel-ID 303, Seite 1-14 |
ISSN Quelle: | 2072-6643 |
Abstract: | As a consequence of epidemiological studies showing significant associations of vitamin D deficiency with a variety of adverse extra-skeletal clinical outcomes including cardiovascular diseases, cancer, and mortality, large vitamin D randomized controlled trials (RCTs) have been designed and conducted over the last few years. The vast majority of these trials did not restrict their study populations to individuals with vitamin D deficiency, and some even allowed moderate vitamin D supplementation in the placebo groups. In these RCTs, there were no significant effects on the primary outcomes, including cancer, cardiovascular events, and mortality, but explorative outcome analyses and meta-analyses revealed indications for potential benefits such as reductions in cancer mortality or acute respiratory infections. Importantly, data from RCTs with relatively high doses of vitamin D supplementation did, by the vast majority, not show significant safety issues, except for trials in critically or severely ill patients or in those using very high intermittent vitamin D doses. The recent large vitamin D RCTs did not challenge the beneficial effects of vitamin D regarding rickets and osteomalacia, that therefore continue to provide the scientific basis for nutritional vitamin D guidelines and recommendations. There remains a great need to evaluate the effects of vitamin D treatment in populations with vitamin D deficiency or certain characteristics suggesting a high sensitivity to treatment. Outcomes and limitations of recently published large vitamin D RCTs must inform the design of future vitamin D or nutrition trials that should use more personalized approaches. |
DOI: | doi:10.3390/nu14020303 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.3390/nu14020303 |
| kostenfrei: Volltext: https://www.mdpi.com/2072-6643/14/2/303 |
| DOI: https://doi.org/10.3390/nu14020303 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | cholecalciferol |
| clinical trial |
| epidemiology |
| infections |
| mortality |
| randomized controlled trial |
| RCT |
| supplementation |
| vitamin D |
K10plus-PPN: | 1846948193 |
Verknüpfungen: | → Zeitschrift |
Critical appraisal of large vitamin D randomized controlled trials / Pilz, Stefan [VerfasserIn]; 12 January 2022 (Online-Ressource)