| |  Online-Ressource |
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| Verfasst von: | Scharnholz, Barbara [VerfasserIn]  |
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| | Weber-Hamann, Bettina [VerfasserIn] |
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| | Lederbogen, Florian [VerfasserIn] |
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| | Schilling, Claudia [VerfasserIn] |
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| | Gilles, Maria [VerfasserIn] |
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| | Onken, Vera [VerfasserIn] |
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| | Frankhauser, Pascal [VerfasserIn] |
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| | Kopf, Daniel [VerfasserIn] |
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| | Deuschle, Michael [VerfasserIn] |
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| Titel: | Antidepressant treatment with mirtazapine, but not venlafaxine, lowers cortisol concentrations in saliva |
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| Titelzusatz: | A randomised open trial |
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| Verf.angabe: | Barbara Scharnholz, Bettina Weber-Hamann, Florian Lederbogen, Claudia Schilling, Maria Gilles, Vera Onken, Pascal Frankhauser, Daniel Kopf, Michael Deuschle |
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| E-Jahr: | 2010 |
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| Jahr: | 8 April 2010 |
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| Umfang: | 5 S. |
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| Fussnoten: | Gesehen am 31.05.2023 |
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| Titel Quelle: | Enthalten in: Psychiatry research |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1979 |
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| Jahr Quelle: | 2010 |
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| Band/Heft Quelle: | 177(2010), 1/2 vom: Mai, Seite 109-113 |
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| ISSN Quelle: | 1872-7123 |
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| Abstract: | Lowering the concentrations of free cortisol in depressed patients may be an important prerequisite to prevent glucocorticoid-related sequelae of depression. We tested the hypothesis that the hypothalamus-pituitary-adrenal (HPA) system-dampening effects of venlafaxine and mirtazapine differ. We compared the course of morning (08.00h) and afternoon saliva cortisol (16.00h) in 42 mirtazapine- and 45 venlafaxine-treated depressed patients during a 1-week wash-out and a 4-week treatment period in a randomised open trial. Mirtazapine lowered afternoon cortisol from week 1 to 4. In contrast, during the course of the entire treatment period, venlafaxine did not attenuate saliva cortisol concentrations. Treatment effects of mirtazapine on cortisol concentrations did not differ in remitters and non-remitters to treatment. High baseline cortisol concentrations, on the other hand, were related to an unfavourable course during venlafaxine treatment and patients remitting during venlafaxine treatment had significantly lower afternoon cortisol concentrations in saliva, when compared to non-remitting patients. Thus, mirtazapine and venlafaxine show different effects on HPA system activity as measured by saliva cortisol. This may be of relevance with regard to physical sequelae of depression. |
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| DOI: | doi:10.1016/j.psychres.2009.08.010 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.psychres.2009.08.010 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S0165178109003163 |
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| | DOI: https://doi.org/10.1016/j.psychres.2009.08.010 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Antidepressants |
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| | Depression |
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| | HPA system |
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| | Psychopharmacology |
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| | Remission |
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| | Response |
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| K10plus-PPN: | 1847004172 |
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| Verknüpfungen: | → Zeitschrift |
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Antidepressant treatment with mirtazapine, but not venlafaxine, lowers cortisol concentrations in saliva / Scharnholz, Barbara [VerfasserIn]; 8 April 2010 (Online-Ressource)
