AMPA GluR-A receptor subunit mediates hippocampal responsiveness in mice exposed to stress

• Verfasst von: Fumagalli, Fabio [VerfasserIn]
• Verfasst von: Caffino, Lucia [VerfasserIn]
• Verfasst von: Vogt, Miriam A. [VerfasserIn]
• Verfasst von: Frasca, Angelisa [VerfasserIn]
• Verfasst von: Racagni, Giorgio [VerfasserIn]
• Verfasst von: Sprengel, Rolf [VerfasserIn]
• Verfasst von: Gass, Peter [VerfasserIn]
• Verfasst von: Riva, Marco Andrea [VerfasserIn]
• Titel: AMPA GluR-A receptor subunit mediates hippocampal responsiveness in mice exposed to stress
• Verf.angabe: Fabio Fumagalli, Lucia Caffino, Miriam A. Vogt, Angelisa Frasca, Giorgio Racagni, Rolf Sprengel, Peter Gass, and Marco Andrea Riva
• E-Jahr: 2011
• Jahr: 23. August 2011
• Umfang: 8 S.
• Fussnoten: Gesehen am 01.06.2023 ; Erscheinungsjahr im PDF: Online veröffentlicht am 22. Juni 2010, Urheberrecht: 2010 Wiley-Liss, Inc. ; Erscheinungsjahr auf der Frontdoor: Erstmals veröffentlicht: 23. August 2011
• Titel Quelle: Enthalten in: Hippocampus
• Ort Quelle: New York, NY [u.a.] : Wiley, 1991
• Jahr Quelle: 2011
• Band/Heft Quelle: 21(2011), 9 vom: Sept., Seite 1028-1035
• ISSN Quelle: 1098-1063
• DOI: doi:10.1002/hipo.20817
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: activity regulated cytoskeletal-associated protein
• Sach-SW: CaMKII
• Sach-SW: glucocorticoids
• Sach-SW: glutamate
• Sach-SW: NMDA receptors
• Sach-SW: synapsin I
• K10plus-PPN: 1847126332

Abstract

Because stress represents a major precipitating event for psychiatric disorders, it is important to identify molecular mechanisms that may be altered in vulnerable individuals when exposed to stress. Here, we studied GluR-A−/− mice, animals with compromised AMPA receptor signaling, and characterized by a schizophrenic as well as depressive phenotype to investigate changes occurring in response to an acute stress. Wild-type and GluR-A−/− mice were exposed to a single immobilization stress and sacrificed immediately after the end of the stress for the analysis of activity regulated genes and of glutamatergic synapse responsiveness. The acute stress produced a marked increase in the hippocampal expression of Arc (activity-regulated cytoskeletal-associated protein) in GluR-A−/−, but not in wild-type mice, which was associated with a similar increase of phospho-CaMKII, a partner in the action of Arc. When looking at the glutamatergic response to stress in wild-type animals, we found that stress increased GluR-A phosphorylation on serine831, an effect that was paralleled by a significant increase of the phosphorylation of the main NMDA receptor subunits, that is, NR-1 and NR-2B. Conversely, the stress-induced modulation of NMDA receptor subunits was not observed in GluR-A−/− mice. We suggest that enhanced stress responsiveness in GluR-A−/− mice may be due, at least in part, to their inability to activate NMDA-mediated glutamatergic neurotransmission, suggesting that the integrity of AMPA/NMDA receptor function may be important for successful coping under stressful conditions. © 2010 Wiley-Liss, Inc.