Carbon ion radiation therapy for high-risk meningiomas

• Verfasst von: Combs, Stephanie [VerfasserIn]
• Verfasst von: Hartmann, Christian [VerfasserIn]
• Verfasst von: Nikoghosyan, Anna [VerfasserIn]
• Verfasst von: Jäkel, Oliver [VerfasserIn]
• Verfasst von: Karger, Christian [VerfasserIn]
• Verfasst von: Haberer, Thomas [VerfasserIn]
• Verfasst von: Deimling, Andreas von [VerfasserIn]
• Verfasst von: Münter, Marc [VerfasserIn]
• Verfasst von: Huber, Peter E. [VerfasserIn]
• Verfasst von: Debus, Jürgen [VerfasserIn]
• Verfasst von: Schulz-Ertner, Daniela [VerfasserIn]
• Titel: Carbon ion radiation therapy for high-risk meningiomas
• Verf.angabe: Stephanie E. Combs, Christian Hartmann, Anna Nikoghosyan, Oliver Jäkel, Christian P. Karger, Thomas Haberer, Andreas von Deimling, Marc W. Münter, Peter E. Huber, Jürgen Debus, Daniela Schulz-Ertner
• E-Jahr: 2010
• Jahr: 25 February 2010
• Umfang: 6 S.
• Fussnoten: Gesehen am 05.06.2023
• Titel Quelle: Enthalten in: Radiotherapy and oncology
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1983
• Jahr Quelle: 2010
• Band/Heft Quelle: 95(2010), 1, Seite 54-59
• ISSN Quelle: 1879-0887
• DOI: doi:10.1016/j.radonc.2009.12.029
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Aged
• Sach-SW: Humans
• Sach-SW: Female
• Sach-SW: Male
• Sach-SW: Adult
• Sach-SW: Middle Aged
• Sach-SW: Photons
• Sach-SW: Risk
• Sach-SW: Radiotherapy, Intensity-Modulated
• Sach-SW: Meningeal Neoplasms
• Sach-SW: Meningioma
• Sach-SW: Heavy Ion Radiotherapy
• Sach-SW: Carbon
• K10plus-PPN: 1847387497

Abstract

BACKGROUND: We analyzed outcome after a carbon ion boost in combination with precision photon radiation therapy in patients with meningiomas. - PATIENTS AND METHODS: Ten patients with meningiomas were treated with carbon ion RT as part of a Phase I/II trial. Carbon ion RT was conducted in conjunction with fractionated stereotactic RT (FSRT) or intensity-modulated RT (IMRT). Eight patients were treated as primary RT, in 2 patients carbon ion RT was performed as re-irradiation. Carbon ion RT was applied with a median dose of 18 GyE, and photon RT was applied with a median dose of 50.4 Gy. Two patients with a history of former irradiation received 18GyE of carbon ion RT and a reduced dose of photon treatment. - RESULTS: The median follow-up time was 77 months. Five patients died during follow-up, of which four died of tumor progression. In the group treated in the primary situation, actuarial survival rates after RT were 75% and 63% at 5 and 7 years. After re-irradiation, both patients died at 10 and 67 months, respectively. Actuarial local control rates after primary RT were 86% and 72% at 5 and 7 years. Two patients developed tumor recurrence after re-irradiation, 6 and 67 months after treatment. - CONCLUSION: In conclusion, carbon ion radiation shows promising results in patients with atypical or anaplastic meningiomas. Further evaluation in a larger, prospective study in comparison to proton RT or modern photon RT is needed to corroborate these results.