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| Verfasst von: | Conter, Valentino [VerfasserIn]  |
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| | Bartram, Claus R. [VerfasserIn] |
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| | Valsecchi, Maria Grazia [VerfasserIn] |
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| | Schrauder, André [VerfasserIn] |
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| | Panzer-Grümayer, Renate [VerfasserIn] |
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| | Möricke, Anja [VerfasserIn] |
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| | Aricò, Maurizio [VerfasserIn] |
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| | Zimmermann, Martin [VerfasserIn] |
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| | Mann, Georg [VerfasserIn] |
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| | De Rossi, Giulio [VerfasserIn] |
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| | Stanulla, Martin [VerfasserIn] |
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| | Locatelli, Franco [VerfasserIn] |
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| | Basso, Giuseppe [VerfasserIn] |
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| | Niggli, Felix [VerfasserIn] |
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| | Barisone, Elena [VerfasserIn] |
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| | Henze, Günter [VerfasserIn] |
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| | Ludwig, Wolf-Dieter [VerfasserIn] |
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| | Haas, Oskar A. [VerfasserIn] |
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| | Cazzaniga, Giovanni [VerfasserIn] |
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| | Köhler, Rolf [VerfasserIn] |
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| | Silvestri, Daniela [VerfasserIn] |
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| | Bradtke, Jutta [VerfasserIn] |
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| | Parasole, Rosanna [VerfasserIn] |
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| | Beier, Rita [VerfasserIn] |
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| | van Dongen, Jacques J. M. [VerfasserIn] |
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| | Biondi, Andrea [VerfasserIn] |
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| | Schrappe, Martin [VerfasserIn] |
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| Titel: | Molecular response to treatment redefines all prognostic factors in children and adolescents with B-cell precursor acute lymphoblastic leukemia |
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| Titelzusatz: | results in 3184 patients of the AIEOP-BFM ALL 2000 study |
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| Verf.angabe: | Valentino Conter, Claus R. Bartram, Maria Grazia Valsecchi, André Schrauder, Renate Panzer-Grümayer, Anja Möricke, Maurizio Aricò, Martin Zimmermann, Georg Mann, Giulio De Rossi, Martin Stanulla, Franco Locatelli, Giuseppe Basso, Felix Niggli, Elena Barisone, Günter Henze, Wolf-Dieter Ludwig, Oskar A. Haas, Giovanni Cazzaniga, Rolf Koehler, Daniela Silvestri, Jutta Bradtke, Rosanna Parasole, Rita Beier, Jacques J.M. van Dongen, Andrea Biondi, and Martin Schrappe |
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| E-Jahr: | 2010 |
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| Jahr: | 14 December 2020 |
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| Umfang: | 9 S. |
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| Fussnoten: | Gesehen am 06.06.2023 |
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| Titel Quelle: | Enthalten in: Blood |
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| Ort Quelle: | Washington, DC : American Society of Hematology, 1946 |
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| Jahr Quelle: | 2010 |
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| Band/Heft Quelle: | 115(2010), 16, Seite 3206-3214 |
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| ISSN Quelle: | 1528-0020 |
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| Abstract: | The Associazione Italiana di Ematologia Oncologia Pediatrica and the Berlin-Frankfurt-Münster Acute Lymphoblastic Leukemia (AIEOP-BFM ALL 2000) study has for the first time introduced standardized quantitative assessment of minimal residual disease (MRD) based on immunoglobulin and T-cell receptor gene rearrangements as polymerase chain reaction targets (PCR-MRD), at 2 time points (TPs), to stratify patients in a large prospective study. Patients with precursor B (pB) ALL (n = 3184) were considered MRD standard risk (MRD-SR) if MRD was already negative at day 33 (analyzed by 2 markers, with a sensitivity of at least 10(-4)); MRD high risk (MRD-HR) if 10(-3) or more at day 78 and MRD intermediate risk (MRD-IR): others. MRD-SR patients were 42% (1348): 5-year event-free survival (EFS, standard error) is 92.3% (0.9). Fifty-two percent (1647) were MRD-IR: EFS 77.6% (1.3). Six percent of patients (189) were MRD-HR: EFS 50.1% (4.1; P < .001). PCR-MRD discriminated prognosis even on top of white blood cell count, age, early response to prednisone, and genotype. MRD response detected by sensitive quantitative PCR at 2 predefined TPs is highly predictive for relapse in childhood pB-ALL. The study is registered at http://clinicaltrials.gov: NCT00430118 for BFM and NCT00613457 for AIEOP. |
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| DOI: | doi:10.1182/blood-2009-10-248146 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1182/blood-2009-10-248146 |
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| | DOI: https://doi.org/10.1182/blood-2009-10-248146 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Adolescent |
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| | Antineoplastic Combined Chemotherapy Protocols |
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| | Biomarkers, Tumor |
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| | Child |
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| | Child, Preschool |
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| | Disease-Free Survival |
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| | Gene Rearrangement, B-Lymphocyte |
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| | Gene Rearrangement, T-Lymphocyte |
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| | Humans |
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| | Infant |
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| | Kaplan-Meier Estimate |
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| | Neoplasm, Residual |
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| | Precursor Cell Lymphoblastic Leukemia-Lymphoma |
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| | Prognosis |
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| | Receptors, Antigen, B-Cell |
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| | Receptors, Antigen, T-Cell |
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| | Remission Induction |
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| | Reverse Transcriptase Polymerase Chain Reaction |
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| | Treatment Outcome |
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| K10plus-PPN: | 1847529275 |
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| Verknüpfungen: | → Zeitschrift |
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Molecular response to treatment redefines all prognostic factors in children and adolescents with B-cell precursor acute lymphoblastic leukemia / Conter, Valentino [VerfasserIn]; 14 December 2020 (Online-Ressource)
