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| Verfasst von: | Fösleitner, Olivia [VerfasserIn]  |
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| | Knop, Karl Christian [VerfasserIn] |
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| | Lindenau, Matthias [VerfasserIn] |
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| | Preisner, Fabian [VerfasserIn] |
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| | Bäumer, Philipp [VerfasserIn] |
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| | Heiland, Sabine [VerfasserIn] |
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| | Bendszus, Martin [VerfasserIn] |
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| | Kronlage, Moritz [VerfasserIn] |
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| Titel: | Quantitative MR neurography in multifocal motor neuropathy and amyotrophic lateral sclerosis |
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| Verf.angabe: | Olivia Foesleitner, Karl Christian Knop, Matthias Lindenau, Fabian Preisner, Philipp Bäumer, Sabine Heiland, Martin Bendszus and Moritz Kronlage |
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| E-Jahr: | 2023 |
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| Jahr: | 25 March 2023 |
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| Umfang: | 12 S. |
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| Fussnoten: | Gesehen am 09.06.2023 |
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| Titel Quelle: | Enthalten in: Diagnostics |
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| Ort Quelle: | Basel : MDPI, 2011 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 13(2023), 7 vom: März, Artikel-ID 1237, Seite 1-12 |
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| ISSN Quelle: | 2075-4418 |
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| Abstract: | Background: The aim of this study was to assess the phenotype of multifocal motor neuropathy (MMN) and amyotrophic lateral sclerosis (ALS) in quantitative MR neurography. Methods: In this prospective study, 22 patients with ALS, 8 patients with MMN, and 10 healthy volunteers were examined with 3T MR neurography, using a high-resolution fat-saturated T2-weighted sequence, diffusion-tensor imaging (DTI), and a multi-echo T2-relaxometry sequence. The quantitative biomarkers fractional anisotropy (FA), radial and axial diffusivity (RD, AD), mean diffusivity (MD), cross-sectional area (CSA), T2-relaxation time, and proton spin density (PSD) were measured in the tibial nerve at the thigh and calf, and in the median, radial, and ulnar nerves at the mid-upper arm. Results: MMN showed a characteristic imaging pattern of decreased FA (p = 0.018), increased RD (p = 0.014), increased CSA (p < 0.001), increased T2-relaxation time (p < 0.001), and increased PSD (p = 0.025) in the upper arm nerves compared to ALS and controls. ALS patients did not differ from controls in any imaging marker, nor were there any group differences in the tibial nerve (p > 0.05). Conclusions: MMN shows a characteristic pattern of quantitative DTI and T2-relaxometry parameters in the upper-arm nerves, primarily indicating demyelination. Peripheral nerve changes in ALS seem to be below the detection level of current state-of-the-art quantitative MR neurography. |
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| DOI: | doi:10.3390/diagnostics13071237 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.3390/diagnostics13071237 |
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| | Volltext: https://www.mdpi.com/2075-4418/13/7/1237 |
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| | DOI: https://doi.org/10.3390/diagnostics13071237 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | amyotrophic lateral sclerosis |
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| | diagnostic imaging |
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| | diffusion magnetic resonance imaging |
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| | diffusion tensor imaging |
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| | peripheral nervous system diseases |
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| K10plus-PPN: | 1848511671 |
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| Verknüpfungen: | → Zeitschrift |
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Quantitative MR neurography in multifocal motor neuropathy and amyotrophic lateral sclerosis / Fösleitner, Olivia [VerfasserIn]; 25 March 2023 (Online-Ressource)
