Asynchronous calibration of quantitative computed tomography bone mineral density assessment for opportunistic osteoporosis screening

• Verfasst von: Skornitzke, Stephan [VerfasserIn]
• Verfasst von: Vats, Neha [VerfasserIn]
• Verfasst von: Kopytova, Taisiya G. [VerfasserIn]
• Verfasst von: Tong, Elizabeth Wai Yee [VerfasserIn]
• Verfasst von: Hofbauer, Tobias [VerfasserIn]
• Verfasst von: Weber, Tim [VerfasserIn]
• Verfasst von: Rehnitz, Christoph [VerfasserIn]
• Verfasst von: Stackelberg, Oyunbileg von [VerfasserIn]
• Verfasst von: Maier-Hein, Klaus H. [VerfasserIn]
• Verfasst von: Stiller, Wolfram [VerfasserIn]
• Verfasst von: Biederer, Jürgen [VerfasserIn]
• Verfasst von: Kauczor, Hans-Ulrich [VerfasserIn]
• Verfasst von: Heußel, Claus Peter [VerfasserIn]
• Verfasst von: Wielpütz, Mark Oliver [VerfasserIn]
• Verfasst von: Palm, Viktoria [VerfasserIn]
• Titel: Asynchronous calibration of quantitative computed tomography bone mineral density assessment for opportunistic osteoporosis screening
• Titelzusatz: phantom-based validation and parameter influence evaluation
• Verf.angabe: Stephan Skornitzke, Neha Vats, Taisiya Kopytova, Elizabeth Wai Yee Tong, Tobias Hofbauer, Tim Frederik Weber, Christoph Rehnitz, Oyunbileg von Stackelberg, Klaus Maier-Hein, Wolfram Stiller, Jürgen Biederer, Hans-Ulrich Kauczor, Claus-Peter Heußel, Mark Wielpütz & Viktoria Palm
• E-Jahr: 2022
• Jahr: 01 December 2022
• Umfang: 9 S.
• Illustrationen: Illustrationen
• Fussnoten: Gesehen am 12.06.2023
• Titel Quelle: Enthalten in: Scientific reports
• Ort Quelle: [London] : Macmillan Publishers Limited, part of Springer Nature, 2011
• Jahr Quelle: 2022
• Band/Heft Quelle: 12(2022), Artikel-ID 20729, Seite 1-9
• ISSN Quelle: 2045-2322
• DOI: doi:10.1038/s41598-022-24546-2
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Bone imaging
• Sach-SW: Computed tomography
• Sach-SW: Diagnosis
• Sach-SW: Diseases
• Sach-SW: Endocrinology
• Sach-SW: Health care
• Sach-SW: Medical imaging
• Sach-SW: Metabolic bone disease
• Sach-SW: Osteoporosis
• Sach-SW: Tomography
• K10plus-PPN: 1848831919
• K10plus-PPN:
  Universitätsbibliothek
• Lokale URL UB: Zum Volltext

Abstract

Asynchronous calibration could allow opportunistic screening based on routine CT for early osteoporosis detection. In this phantom study, a bone mineral density (BMD) calibration phantom and multi-energy CT (MECT) phantom were imaged on eight different CT scanners with multiple tube voltages (80-150 kVp) and image reconstruction settings (e.g. soft/hard kernel). Reference values for asynchronous BMD estimation were calculated from the BMD-phantom and validated with six calcium composite inserts of the MECT-phantom with known ground truth. Relative errors/changes in estimated BMD were calculated and investigated for influence of tube voltage, CT scanner and reconstruction setting. Reference values for 282 acquisitions were determined, resulting in an average relative error between calculated BMD and ground truth of − 9.2% ± 14.0% with a strong correlation (R2 = 0.99; p < 0.0001). Tube voltage and CT scanner had a significant effect on calculated BMD (p < 0.0001), with relative differences in BMD of 3.8% ± 28.2% when adapting reference values for tube voltage, − 5.6% ± 9.2% for CT scanner and 0.2% ± 0.2% for reconstruction setting, respectively. Differences in BMD were small when using reference values from a different CT scanner of the same model (0.0% ± 1.4%). Asynchronous phantom-based calibration is feasible for opportunistic BMD assessment based on CT images with reference values adapted for tube voltage and CT scanner model.