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| Verfasst von: | Jin, Fukang [VerfasserIn]  |
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| | Zhu, Lei [VerfasserIn] |
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| | Shao, Jingbo [VerfasserIn] |
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| | Yakoub, Mina [VerfasserIn] |
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| | Schmitt, Lukas [VerfasserIn] |
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| | Reißfelder, Christoph [VerfasserIn] |
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| | Loges, Sonja [VerfasserIn] |
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| | Benner, Axel [VerfasserIn] |
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| | Schölch, Sebastian [VerfasserIn] |
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| Titel: | Circulating tumour cells in patients with lung cancer universally indicate poor prognosis |
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| Titelzusatz: | review |
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| Verf.angabe: | Fukang Jin, Lei Zhu, Jingbo Shao, Mina Yakoub, Lukas Schmitt, Christoph Reißfelder, Sonja Loges, Axel Benner and Sebastian Schölch |
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| E-Jahr: | 2022 |
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| Jahr: | December 14, 2022 |
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| Umfang: | 14 S. |
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| Fussnoten: | Gesehen am 12.06.2023 |
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| Titel Quelle: | Enthalten in: European respiratory review |
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| Ort Quelle: | Sheffield : Soc., 2005 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 31(2022), 166, Artikel-ID 220151, Seite 1-14 |
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| ISSN Quelle: | 1600-0617 |
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| Abstract: | Background: In lung cancer, the relevance of various circulating tumour cell (CTC) subgroups in different lung cancer subtypes is unclear. We performed a comprehensive meta-analysis to assess the prognostic value of CTCs in the different histological types of lung cancer, with particular respect to CTC subtypes, cut-offs and time points of CTC enumeration. - Methods: We searched MEDLINE, Web of Science and Embase alongside relevant studies evaluating the prognostic value of CTCs in lung cancer patients. A random-effects model was used for meta-analysis, calculating hazard ratios (HRs), 95% confidence intervals and p-values. - Results: 27 studies enrolling 2957 patients were included. CTC detection indicates poor prognosis, especially in small cell lung cancer (SCLC) patients (overall survival HR 3.11, 95% CI 2.59-3.73) and predicts a worse outcome compared to nonsmall cell lung cancer patients. Epithelial CTCs predict a worse outcome for lung cancer than mesenchymal CTCs or epithelial-mesenchymal hybrids. - Conclusion: CTCs indicate poor prognosis in patients with primary lung cancer, with CTCs in SCLC having a more pronounced prognostic effect. The prognostic value of CTCs detected by different markers varies; most evidence is available for the strong negative prognostic effect of epithelial CTCs. - Tweetable abstract ERSpublications - click to tweetThis meta-analysis demonstrates that the prognostic value of epithelial CTCs is greater than that of mesenchymal CTCs in lung cancer. CTCs indicate poor prognosis in all subtypes of lung cancer; this effect increases with CTC detection thresholds. https://bit.ly/3dhlY0C |
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| DOI: | doi:10.1183/16000617.0151-2022 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1183/16000617.0151-2022 |
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| | kostenfrei: Volltext: http://err.ersjournals.com/content/31/166/220151 |
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| | DOI: https://doi.org/10.1183/16000617.0151-2022 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1848834969 |
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| Verknüpfungen: | → Zeitschrift |
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Circulating tumour cells in patients with lung cancer universally indicate poor prognosis / Jin, Fukang [VerfasserIn]; December 14, 2022 (Online-Ressource)
