| |  Online-Ressource |
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| Verfasst von: | Kim, Hi Chul [VerfasserIn]  |
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| | El-Khoury, Victoria [VerfasserIn] |
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| | Schulte, Nadine [VerfasserIn] |
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| | Zhan, Tianzuo [VerfasserIn] |
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| | Betge, Johannes [VerfasserIn] |
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| | Cousin, Loic [VerfasserIn] |
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| | Felli, Emanuele [VerfasserIn] |
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| | Pessaux, Patrick [VerfasserIn] |
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| | Ogier, Arnaud [VerfasserIn] |
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| | Opitz, Oliver [VerfasserIn] |
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| | Ku, Bosung [VerfasserIn] |
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| | Ebert, Matthias [VerfasserIn] |
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| | Kwon, Yong-Jun [VerfasserIn] |
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| Titel: | Personalized functional profiling using ex-vivo patient-derived spheroids points out the potential of an antiangiogenic treatment in a patient with a metastatic lung atypical carcinoid |
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| Titelzusatz: | bedside-to-bench report |
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| Verf.angabe: | Hichul Kim, Victoria El-Khoury, Nadine Schulte, Tianzuo Zhan, Johannes Betge, Loic Cousin, Emanuele Felli, Patrick Pessaux, Arnaud Ogier, Oliver G Opitz, Bosung Ku, Matthias P Ebert, and Yong-Jun Kwon |
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| E-Jahr: | 2022 |
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| Jahr: | 22 Feb 2022 |
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| Umfang: | 7 S. |
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| Fussnoten: | Gesehen am 13.06.2023 |
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| Titel Quelle: | Enthalten in: Cancer biology & therapy |
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| Ort Quelle: | London : Informa UK Limited, Taylor & Francis Group, 2002 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 23(2022), 1, Seite 96-102 |
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| ISSN Quelle: | 1555-8576 |
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| Abstract: | Lung carcinoids are neuroendocrine tumors representing 1 to 2% of lung cancers. This study outlines the case of a patient with a metastatic lung atypical carcinoid who presented with a pleural effusion and progression of liver metastases after developing resistance to conventional treatments. Personalized functional profiling (PFP), i.e. drug screening, was performed in ex-vivo spheroids obtained from the patient’s liver metastasis to identify potential therapeutic options. The drug screening results revealed cediranib, an antiangiogenic drug, as a hit drug for this patient, from a library of 66 Food and Drug Administration (FDA)-approved and investigational drugs. Based on the PFP results and the reported evidence of clinical efficacy of bevacizumab and capecitabine combination in gastro-intestinal neuroendocrine tumors, this combination was given to the patient. Four months later, the pleural effusion and pleura carcinosis regressed and the liver metastasis did not progress. The patient experienced 2 years of a stable disease under the PFP-guided personalized treatment. |
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| DOI: | doi:10.1080/15384047.2021.2021042 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1080/15384047.2021.2021042 |
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| | kostenfrei: Volltext: https://www.tandfonline.com/doi/full/10.1080/15384047.2021.2021042 |
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| | DOI: https://doi.org/10.1080/15384047.2021.2021042 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | antiangiogenic therapy |
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| | drug screening |
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| | lung carcinoid |
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| | neuroendocrine tumors |
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| | Personalized functional profiling |
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| | personalized medicine |
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| | pharmacotyping |
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| | precision medicine |
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| | spheroids |
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| K10plus-PPN: | 1848869290 |
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| Verknüpfungen: | → Zeitschrift |
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Personalized functional profiling using ex-vivo patient-derived spheroids points out the potential of an antiangiogenic treatment in a patient with a metastatic lung atypical carcinoid / Kim, Hi Chul [VerfasserIn]; 22 Feb 2022 (Online-Ressource)
