| |  Online-Ressource |
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| Verfasst von: | Kurz, Felix T. [VerfasserIn]  |
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| | Aon, Miguel A. [VerfasserIn] |
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| | Schlemmer, Heinz-Peter [VerfasserIn] |
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| | Jende, Johann [VerfasserIn] |
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| | O’Rourke, Brian [VerfasserIn] |
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| | Armoundas, Antonis A. [VerfasserIn] |
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| Titel: | Fractal dynamics of individual mitochondrial oscillators measure local inter-mitochondrial coupling |
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| Verf.angabe: | Felix T. Kurz, Miguel A. Aon, Heinz-Peter Schlemmer, Johann M.E. Jende, Brian O’Rourke, and Antonis A. Armoundas |
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| E-Jahr: | 2023 |
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| Jahr: | 18 April 2023 |
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| Umfang: | 11 S. |
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| Fussnoten: | Online verfügbar 10. März 2023, Artikelversion 18. April 2023 ; Gesehen am 14.06.2023 |
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| Titel Quelle: | Enthalten in: Biophysical journal |
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| Ort Quelle: | Cambridge, Mass. : Cell Press, 1960 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 122(2023), 8 vom: Apr., Seite 1459-1469 |
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| ISSN Quelle: | 1542-0086 |
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| Abstract: | Mitochondrial inner membrane potentials in cardiomyocytes may oscillate in cycles of depolarization/repolarization when the mitochondrial network is exposed to metabolic or oxidative stress. The frequencies of such oscillations are dynamically changing while clusters of weakly coupled mitochondrial oscillators adjust to a common phase and frequency. Across the cardiac myocyte, the averaged signal of the mitochondrial population follows self-similar or fractal dynamics; however, fractal properties of individual mitochondrial oscillators have not yet been examined. We show that the largest synchronously oscillating cluster exhibits a fractal dimension, D, that is indicative of self-similar behavior with D=1.27±0.11, in contrast to the remaining network mitochondria whose fractal dimension is close to that of Brownian noise, D=1.58±0.10. We further demonstrate that fractal behavior is correlated with local coupling mechanisms, whereas it is only weakly linked to measures of functional connections between mitochondria. Our findings suggest that individual mitochondrial fractal dimensions may serve as a simple measure of local mitochondrial coupling. |
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| DOI: | doi:10.1016/j.bpj.2023.03.011 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.bpj.2023.03.011 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S0006349523001649 |
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| | DOI: https://doi.org/10.1016/j.bpj.2023.03.011 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 184897471X |
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| Verknüpfungen: | → Zeitschrift |
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Fractal dynamics of individual mitochondrial oscillators measure local inter-mitochondrial coupling / Kurz, Felix T. [VerfasserIn]; 18 April 2023 (Online-Ressource)
