Impact of HLA mismatching on incidence of posttransplant non-Hodgkin lymphoma after kidney transplantation

• Verfasst von: Opelz, Gerhard [VerfasserIn]
• Verfasst von: Döhler, Bernd [VerfasserIn]
• Titel: Impact of HLA mismatching on incidence of posttransplant non-Hodgkin lymphoma after kidney transplantation
• Verf.angabe: Gerhard Opelz and Bernd Döhler
• Jahr: 2010
• Umfang: 6 S.
• Fussnoten: Gesehen am 14.06.2023
• Titel Quelle: Enthalten in: Transplantation
• Ort Quelle: Hagerstown, Md. : Lippincott Williams & Wilkins, 1963
• Jahr Quelle: 2010
• Band/Heft Quelle: 89(2010), 5 vom: 15. März, Seite 567-572
• ISSN Quelle: 1534-6080
• DOI: doi:10.1097/TP.0b013e3181c69855
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1848979355

Abstract

Background. - Posttransplant non-Hodgkin lymphoma is a rare complication but associated with high mortality. The extent to which human leukocyte antigen (HLA) mismatching influences the rate of posttransplant lymphoma has not been clarified. - Methods. - Data on lymphomas occurring in the first 3 years posttransplant were analyzed among first kidney transplants from deceased donors performed between 1985 and 2007 and reported to the Collaborative Transplant Study. - Results. -Of 152,728 patients included, 593 non-Hodgkin lymphomas were diagnosed. Cox multivariate regression analysis showed that HLA-A mismatches had no influence on the rate of lymphoma. One and two HLA-DR mismatches were associated with a hazard ratio (HR) of 1.21 (95% confidence interval 1.00-1.45, P=0.047) and 1.56 (95% confidence interval 1.21-1.99, P<0.001), respectively. For lymphoma of the kidney and central nervous system, HRs for two HLA-DR mismatches were 2.29 (P=0.007) and 2.17 (P=0.029), respectively. Two HLA-B mismatches were also significantly associated with lymphoma in the kidney (HR 2.82, P=0.009). - Conclusion. - Mismatches at the HLA-DR locus are a significant risk factor for posttransplant non-Hodgkin lymphoma, particularly in the kidney and central nervous system, whereas two HLA-B mismatches increase the risk for the development of lymphoma of the kidney.