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 Online-Ressource | |
| Verfasst von: | Körper, Sixten [VerfasserIn]  |
| Grüner, Beate [VerfasserIn] | |
| Zickler, Daniel [VerfasserIn] | |
| Wiesmann, Thomas [VerfasserIn] | |
| Wuchter, Patrick [VerfasserIn] | |
| Blasczyk, Rainer [VerfasserIn] | |
| Zacharowski, Kai [VerfasserIn] | |
| Spieth, Peter [VerfasserIn] | |
| Tonn, Torsten [VerfasserIn] | |
| Rosenberger, Peter [VerfasserIn] | |
| Paul, Gregor [VerfasserIn] | |
| Pilch, Jan [VerfasserIn] | |
| Schwäble, Joachim [VerfasserIn] | |
| Bakchoul, Tamam [VerfasserIn] | |
| Thiele, Thomas [VerfasserIn] | |
| Knörlein, Julian [VerfasserIn] | |
| Dollinger, Matthias M. [VerfasserIn] | |
| Krebs, Jörg [VerfasserIn] | |
| Bentz, Martin [VerfasserIn] | |
| Corman, Victor M. [VerfasserIn] | |
| Kilalic, Dzenan [VerfasserIn] | |
| Schmidtke-Schrezenmeier, Gerlinde [VerfasserIn] | |
| Lepper, Philipp M. [VerfasserIn] | |
| Ernst, Lucas [VerfasserIn] | |
| Wulf, Hinnerk [VerfasserIn] | |
| Ulrich, Alexandra [VerfasserIn] | |
| Weiss, Manfred [VerfasserIn] | |
| Kruse, Jan Matthias [VerfasserIn] | |
| Burkhardt, Thomas [VerfasserIn] | |
| Müller, Rebecca [VerfasserIn] | |
| Klüter, Harald [VerfasserIn] | |
| Schmidt, Michael [VerfasserIn] | |
| Jahrsdörfer, Bernd [VerfasserIn] | |
| Lotfi, Ramin [VerfasserIn] | |
| Rojewski, Markus [VerfasserIn] | |
| Appl, Thomas [VerfasserIn] | |
| Mayer, Benjamin [VerfasserIn] | |
| Schnecko, Philipp [VerfasserIn] | |
| Seifried, Erhard [VerfasserIn] | |
| Schrezenmeier, Hubert [VerfasserIn] | |
| Titel: | One-year follow-up of the CAPSID randomized trial for high-dose convalescent plasma in severe COVID-19 patients |
| Verf.angabe: | Sixten Körper, Beate Grüner, Daniel Zickler, Thomas Wiesmann, Patrick Wuchter, Rainer Blasczyk, Kai Zacharowski, Peter Spieth, Torsten Tonn, Peter Rosenberger, Gregor Paul, Jan Pilch, Joachim Schwäble, Tamam Bakchoul, Thomas Thiele, Julian Knörlein, Matthias M. Dollinger, Jörg Krebs, Martin Bentz, Victor M. Corman, Dzenan Kilalic, Gerlinde Schmidtke-Schrezenmeier, Philipp M. Lepper, Lucas Ernst, Hinnerk Wulf, Alexandra Ulrich, Manfred Weiss, Jan Matthias Kruse, Thomas Burkhardt, Rebecca Müller, Harald Klüter, Michael Schmidt, Bernd Jahrsdörfer, Ramin Lotfi, Markus Rojewski, Thomas Appl, Benjamin Mayer, Philipp Schnecko, Erhard Seifried, and Hubert Schrezenmeier |
| E-Jahr: | 2022 |
| Jahr: | November 3, 2022 |
| Umfang: | 14 S. |
| Fussnoten: | Gesehen am 19.06.2023 |
| Titel Quelle: | Enthalten in: The journal of clinical investigation |
| Ort Quelle: | Ann Arbor, Mich. : ASCJ, 1924 |
| Jahr Quelle: | 2022 |
| Band/Heft Quelle: | 132(2022), 24, Artikel-ID e163657, Seite 1-14 |
| ISSN Quelle: | 1558-8238 |
| Abstract: | BACKGROUND: Results of many randomized trials on COVID-19 convalescent plasma (CCP) have been reported, but information on long-term outcome after CCP treatment is limited. The objectives of this extended observation of the randomized CAPSID trial are to assess long-term outcome and disease burden in patients initially treated with or without CCP. METHODS: Of 105 randomized patients, 50 participated in the extended observation. Quality of life (QoL) was assessed by questionnaires and a structured interview. CCP donors (n = 113) with asymptomatic to moderate COVID-19 were included as a reference group.RESULTS: The median follow-up of patients was 396 days, and the estimated 1-year survival was 78.7% in the CCP group and 60.2% in the control (P = 0.08). The subgroup treated with a higher cumulative amount of neutralizing antibodies showed a better 1-year survival compared with the control group (91.5% versus 60.2%, P = 0.01). Medical events and QoL assessments showed a consistent trend for better results in the CCP group without reaching statistical significance. There was no difference in the increase in neutralizing antibodies after vaccination between the CCP and control groups. CONCLUSION: The trial demonstrated a trend toward better outcome in the CCP group without reaching statistical significance. A predefined subgroup analysis showed a significantly better outcome (long-term survival, time to discharge from ICU, and time to hospital discharge) among those who received a higher amount of neutralizing antibodies compared with the control group. A substantial long-term disease burden remains after severe COVID-19. |
| DOI: | doi:10.1172/JCI163657 |
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt. kostenfrei: Volltext: https://doi.org/10.1172/JCI163657 |
| kostenfrei: Volltext: http://www.jci.org/articles/view/163657 | |
| DOI: https://doi.org/10.1172/JCI163657 | |
| Datenträger: | Online-Ressource |
| Sprache: | eng |
| K10plus-PPN: | 1850539014 |
| Verknüpfungen: | → Zeitschrift |
