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| Verfasst von: | Duman, Aset Ceren [VerfasserIn]  |
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| | Di Marco, Barbara [VerfasserIn] |
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| | Nevedomskaya, Ekaterina [VerfasserIn] |
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| | Ulug, Berk [VerfasserIn] |
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| | Lesche, Ralf [VerfasserIn] |
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| | Christian, Sven [VerfasserIn] |
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| | Alfonso, Julieta [VerfasserIn] |
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| Titel: | Targeting fatty acid oxidation via Acyl-CoA binding protein hinders glioblastoma invasion |
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| Verf.angabe: | Ceren Duman, Barbara Di Marco, Ekaterina Nevedomskaya, Berk Ulug, Ralf Lesche, Sven Christian and Julieta Alfonso |
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| E-Jahr: | 2023 |
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| Jahr: | 29 April 2023 |
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| Umfang: | 11 S. |
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| Fussnoten: | Gesehen am 20.06.2023 |
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| Titel Quelle: | Enthalten in: Cell death & disease |
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| Ort Quelle: | London [u.a.] : Nature Publishing Group, 2010 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 14(2023), 4, Artikel-ID 296, Seite 1-11 |
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| ISSN Quelle: | 2041-4889 |
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| Abstract: | The diffuse nature of Glioblastoma (GBM) tumors poses a challenge to current therapeutic options. We have previously shown that Acyl-CoA Binding Protein (ACBP, also known as DBI) regulates lipid metabolism in GBM cells, favoring fatty acid oxidation (FAO). Here we show that ACBP downregulation results in wide transcriptional changes affecting invasion-related genes. In vivo experiments using patient-derived xenografts combined with in vitro models demonstrated that ACBP sustains GBM invasion via binding to fatty acyl-CoAs. Blocking FAO mimics ACBPKD-induced immobility, a cellular phenotype that can be rescued by increasing FAO rates. Further investigation into ACBP-downstream pathways served to identify Integrin beta-1, a gene downregulated upon inhibition of either ACBP expression or FAO rates, as a mediator for ACBP’s role in GBM invasion. Altogether, our findings highlight a role for FAO in GBM invasion and reveal ACBP as a therapeutic vulnerability to stall FAO and subsequent cell invasion in GBM tumors. |
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| DOI: | doi:10.1038/s41419-023-05813-0 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1038/s41419-023-05813-0 |
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| | kostenfrei: Volltext: https://www.nature.com/articles/s41419-023-05813-0 |
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| | DOI: https://doi.org/10.1038/s41419-023-05813-0 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Cancer metabolism |
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| | Cell invasion |
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| K10plus-PPN: | 1850605351 |
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| Verknüpfungen: | → Zeitschrift |
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Targeting fatty acid oxidation via Acyl-CoA binding protein hinders glioblastoma invasion / Duman, Aset Ceren [VerfasserIn]; 29 April 2023 (Online-Ressource)
