Mini-review: the neurobiology of treating substance use disorders with classical psychedelics

• Verfasst von: Urban, Marvin M. [VerfasserIn]
• Verfasst von: Stingl, Moritz [VerfasserIn]
• Verfasst von: Meinhardt, Marcus W. [VerfasserIn]
• Titel: Mini-review: the neurobiology of treating substance use disorders with classical psychedelics
• Verf.angabe: Marvin M. Urban, Moritz R. Stingl and Marcus W. Meinhardt
• E-Jahr: 2023
• Jahr: 17 April 2023
• Umfang: 9 S.
• Fussnoten: Gesehen am 20.06.2023
• Titel Quelle: Enthalten in: Frontiers in neuroscience
• Ort Quelle: Lausanne : Frontiers Research Foundation, 2007
• Jahr Quelle: 2023
• Band/Heft Quelle: 17(2023), Artikel-ID 1156319, Seite 1-9
• ISSN Quelle: 1662-453X
• DOI: doi:10.3389/fnins.2023.1156319
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1850665583
• K10plus-PPN:
  Universitätsbibliothek
• Lokale URL UB: Zum Volltext

Abstract

The potential of psychedelics to persistently treat substance use disorders is known since the 1960s. However, the biological mechanisms responsible for their therapeutic effects have not yet been fully elucidated. While it is known that serotonergic hallucinogens induce changes in gene expression and neuroplasticity, particularly in prefrontal regions, theories on how specifically this counteracts the alterations that occur in neuronal circuitry throughout the course of addiction are largely unknown. This narrative mini-review endeavors to synthesize well-established knowledge from addiction research with findings and theories regarding the neurobiological effects of psychedelics to give an overview of the potential mechanisms that underlie the treatment of substance use disorders with classical hallucinogenic compounds and point out gaps in the current understanding.