| Online-Ressource |
Verfasst von: | Roodenburg, Sharyn [VerfasserIn]  |
| Hartman, Jorine E. [VerfasserIn]  |
| Deslée, Gaëtan [VerfasserIn]  |
| Herth, Felix [VerfasserIn]  |
| Klooster, Karin [VerfasserIn]  |
| Sciurba, Frank [VerfasserIn]  |
| Shah, Pallav [VerfasserIn]  |
| Valipour, Arschang [VerfasserIn]  |
| Zoumot, Zaid [VerfasserIn]  |
| Slebos, Dirk-Jan [VerfasserIn]  |
Titel: | Bronchoscopic lung volume reduction coil treatment for severe emphysema |
Titelzusatz: | a systematic review and meta-analysis of individual participant data |
Verf.angabe: | Sharyn A. Roodenburg, Jorine E. Hartman, Gaëtan Deslée, Felix J.F. Herth, Karin Klooster, Frank C. Sciurba, Pallav L. Shah, Arschang Valipour, Zaid Zoumot, Dirk-Jan Slebos |
E-Jahr: | 2022 |
Jahr: | July 2022 |
Umfang: | 9 S. |
Fussnoten: | Online veröffentlicht: 11. April, 2022 ; Gesehen am 20.06.2023 |
Titel Quelle: | Enthalten in: Respiration |
Ort Quelle: | Basel : Karger, 1968 |
Jahr Quelle: | 2022 |
Band/Heft Quelle: | 101(2022), 7 vom: Juli, Seite 697-705 |
ISSN Quelle: | 1423-0356 |
Abstract: | Background: Lung volume reduction coil (LVR-coil) treatment provides a minimally invasive treatment option for severe emphysema patients which has been studied in multiple clinical trials. Objectives: The aim of the study was to assess the effect of LVR-coil treatment on pulmonary function, quality of life, and exercise capacity using individual participant data. Method: PubMed, Web of Science, and EMBASE were searched until May 17, 2021. Prospective single-arm and randomized controlled trials that evaluated the effect of LVR-coil treatment on forced expiratory volume in 1 s (FEV1), residual volume (RV), St. George Respiratory Questionnaire (SGRQ) total score, and/or 6-min walk distance (6MWD) and were registered in an official clinical trial database were eligible for inclusion. Individual patient data were requested, and a linear mixed effects model was used to calculate overall treatment effects. Results: Eight trials were included in the final analysis, representing 680 individual patients. LVR-coil treatment resulted in a significant improvement in FEV1 at 3- (0.09 L [95% confidence interval (95% CI): 0.06-0.12]) and 6-month follow-up (0.07 L [95% CI: 0.03-0.10]), a significant reduction in RV at 3- (−0.45L [95% CI: −0.62 to −0.28]), 6- (−0.33L [95% CI: −0.52 to −0.14]), and 12-month follow-up (−0.36L [95% CI: −0.64 to −0.08]), a significant reduction in SGRQ total score at 3- (−12.3 points [95% CI: −15.8 to −8.8]), 6- (−10.1 points [95% CI: −12.8 to −7.3]), and 12-month follow-up (−9.8 points [95% CI: −15.0 to −4.7]) and a significant increase in 6MWD at 3-month follow-up (38 m [95% CI: 18-58]). Conclusions: LVR-coil treatment in emphysema patients results in sustained improvements in pulmonary function and quality of life and shorter lived improvements in exercise capacity. Since the owner of this LVR-coil has decided to stop the production and newer generations LVR-coils are currently being developed, these results can act as a reference for future studies and clinical guidance. |
DOI: | doi:10.1159/000524148 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1159/000524148 |
| DOI: https://doi.org/10.1159/000524148 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1850677158 |
Verknüpfungen: | → Zeitschrift |
Bronchoscopic lung volume reduction coil treatment for severe emphysema / Roodenburg, Sharyn [VerfasserIn]; July 2022 (Online-Ressource)